BIOL 404-Exam 4-GI 5
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What are the three enzyme types that break peptides into AAs?
- Cytoplasmic peptidase
Carboxypeptidases, Aminopeptidases and Cytoplasmic peptidases have what activities?
Breaking peptides into AAs
What are the three locations for protein digestion
- 1. In the intestinal lumen.
- 2. At the brush border of the intestinal mucosa.
- 3. In the cytoplasm of the enterocytes.
What does Elastase do?
Breaks down proteint o AAs and oligopeptides
After proteins are broken down to oligopeptides, what happens to them?
hydrolyzed by integral membrane proteins of the brush border
What are the two types of enzymes that breakdown oligopeptides?
What do endopeptidases do?
Cleave internal bonds of oligopeptides
What do Ectopeptidases do?
Cleaves the ends of oligopeptides and dipeptides
What types of protein products can be absorbed?
- Amino Acids
Transport of protein products into the cell is likely linked to what type of ion transporter?
H ion transporter
After absorption, what happens to di and tripeptides?
The bulk are cleaved to AAs by cytosolic peptidases
Are all di and tripeptides broken down in the cytoplasm of the enterocytes?
- Some dipeptides and tripeptides escape intracellular proteolysis and are transported across the enterocyte basolateral plasma membrane intact
Where does absorption of protein products occur?
Primarily in the upper small intestine
Can intact protein be absorbed into the small intestine?
- Yes, in very small amounts
- Via endocytosis and exocytosis
What type transport is needed to move free AAs into the endocytes?
Secondary active transport coupled with Na
What type of protein product requires secondary active transport coupled with protein?
By what mechanism are di/tripeptides carried into the endocytes?
Secondary active transport coupled with H ions
Secondary active transport coupled with H ions carries what protein product into the enterocyte?
Di and Tri-peptides
How are Di and Tri-peptides carried out of the endocytes?
Are dipeptides, tripeptides or AAs absorbed more rapidly?
Di and Tri-peptides
What provides the radiant for secondary active transport of protein products?
Na/K ATPase in the basolateral membrane of the enterocytes
How do AAs exit the enterocyte?
carrier protein mediated facilitated transport
Trypsin is a protein digesting enzyme that is secreted where?
The exocrine cells of the pancreas
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