pharma II test IV adrenocortical hormones

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pharma II test IV adrenocortical hormones
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2013-05-02 00:29:24
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pharma II test IV adrenocortical hormones
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pharma II test IV adrenocortical hormones
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  1. 4 organ and tissue effects of glucocorticoids at higher concentrations
    • lymphocytopenia-immunosuppression
    • stabilizes lysozymes-protects against apoptosis
    • antiinflammatory-inhibit mass cell/basophils
    • osteoporosis - thinning of compact bone
  2. secondary adrenocortical insufficiency results from what
    decreased secretion of ACTH (pituitary)
  3. tertiary adrenocortical insufficiency results from what
    decreased secretion of CRF (hypothalamus)
  4. corticosteroid inhibitor
    moa - inhibits synthesis of cortisol but not that of cortisol presursors
    ind - for diagnostic tests of adrenal function
    metyrapone - metopirone
  5. corticosteroid inhibitor
    moa - blocks conversion of cholesterol to pregnenolone
    ind - adjunct in treatment of steroid-producing adrenocortical cancer
    aminoglutethimide
  6. corticosteroid inhibitor
    moa - blocks sterol synthesis
    ind - adjunct for adrenal carcinoma, hirstism, breast and prostate cancer
    ketocnazole
  7. corticosteroid inhibitor
    moa - binds to glucocorticoid receptor & inhibits release of HSP-complex
    ind - Tx of cushing's syndrome
    mifepristone - RU486
  8. coritcosteroid inhibitor
    moa - antagonist of aldosterone at receptor
    • spironolactone
    • eplereone
  9. mineralcoritcoid
    antiinflammatory
    large salt retention (250X)
    fludrocortisone - florinef
  10. mineralcorticoid
    no antiinflammatory
    lower salt retention (20X)
    desoxycorticosterone - DOC
  11. excessive adrenal secretion
    primary hyperaldosteronism
    Conn's syndrome
  12. Tx of Conn's syndrome
    • surgery
    • spironolactone
    • ACEI
  13. secondary hyperaldosteronism
    hyperactivity of renin-angiotensin system
  14. excessive adrenal secretion
    congenital adrenal hyperplasia
    • deficiency of 21b-hydroxylase
    • decrease glucocorticoids
    • pituitary compensates, increase ACTH release = increased androgen production
  15. Tx of congenital adrenal hyperplasia
    glucocorticoid administration for life
  16. 4 indications for corticosteroids
    • allergic reactions
    • inflammatory disorders
    • lymphatic leukemia
    • brain injury, MI
  17. adverse effect of glucocorticoid
    cushing's disease
  18. Tx of acute adrenal insufficiency (adrenal crisis)
    • fluids
    • salts
    • glucose
    • glucocorticoids
  19. disease of primary adrenocortical insufficiency
    • addison's disease
    • skin pigmentation
  20. Tx of addison's disease
    life-long glucocrticoids and mineralcorticoids
  21. 2 long acting glucocorticoids
    • betamethasone - celestone
    • dexamethasone - decadron
  22. 2 intermediate acting glucocorticoids
    • triamcinolone - aristocort
    • fluprednisolone
  23. 5 short acting glucocorticoids
    • prednisone - deltasone
    • cortisol - hydrocortisone
    • cortisone
    • prednisolone
    • methylprednisolone - medrol
  24. 3 ways glucocorticoids raise blood sugar levels
    • catabolic effect - proteins are broken down to amino acids
    • amino acids are converted to sugar - other than carbohydrates
    • sugars are converted to fat

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