BIOL 404-Exam 4-GI 6
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How much fat do Americans eat daily?
What forms of fats do people eat?
What is a Triacylglyceride?
3 Fatty acids bound to glycerol
What is the basic process of fat emulsification?
Small Fat globules are coated with Bile and phospholipids
Where does triglyceride digestion occur?
Mostly in the small intestine
What is the major digestion enzyme for Fat?
Describe the action of pancreatic lipase:
Water soluble and acts on the surface of Triglycerides
What is the solubility of pancreatic lipase?
What needs to occur for aggregated fat droplets to be efficiently digested?
They need to be broken into smaller droplets, called emulsion droplets
Why are emulsion droplets more efficiently digested?
They have a greater surface area
How are large fat droplets broken down into smaller ones?
By stomach's mechanical movement
How are small fat droplets prevented from re-aggregating in the GI?
Bile and Phospholipids bind to the surface as emulsifying agents
Why are bile salts and phospholipids good emulsifying agents for fat droplets?
They are amphipathic
Name the bile salt covered in class:
What is glycocholic acid?
A bile salt
What limits lipase action on small fat droplets?
Emulsifiers (bile salts and phospholipids)
How does pancreatic lipase gain access to fats covered in emulsifiers?
- Secretes amphipathic protein Collipase
- Collipase binds to fat droplet and binds lipase
What is collipase?
- An amphipathic protein secreted by the pancreas
- Binds to fat droplets and Lipase
- Facilitates Lipase action on emulsion droplets
What are the two phases for the absorption of fat?
- transport into enterocytes
- synthesis and transport of cholomicrons out of epithelial cells
What type of Fat digestion products enter the enterocytes?
Fatty acids and Monoglycerides
How do FA and Monoglycerides enter the enterocytes?
passive diffusion down a concentration gradient
What is the difference between Micelles and emulsion droplets?
- Micelles are much smaller
- They contain digestion products rather than undigested fats
How big are Fat micelles?
Why is absorption enhanced by fat micelles?
Smaller/greater surface area
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