1. What effects of ethanol are the ones that contribute to alcoholic liver disease? (3) 1-1, 2-2, 3-2)
2. What does this lead to? (4)
1. Disrupted intestinal barrier function (increased gut permeability), increased oxidant stress in liver (less available antioxidants and lipid accumulation), activation of immune cells in liver (Kupffer cells, lymphocytes)
2. Steatosis, inflammation, fibrosis, cirrhosis.