PHARM 5 - Asthma

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Author:
dpaytons
ID:
217751
Filename:
PHARM 5 - Asthma
Updated:
2013-05-05 00:36:17
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pharm
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pharm 5
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  1. Albuterol
    • Short acting beta2 adrenergic agonists
    • Bronchodilation
    • Use for rescue relief from bronchoconstriction
  2. Salmeterol
    • Long acting beta2 adrenergic agonists
    • Bronchodilation
    • Most effective with inhaled glucocorticoids
    • Should not be used as monotherapy because of a lack of persistent anti-inflammatory effects
  3. Fluticasone
    • Glucocorticoid - inhalant
    • Anti-inflammatory
    • Inhibition of leukotriene/prostaglandin synthesis
    • Regulation of inflammatory mediators
    • Regulation of norepinephrine and histamine
  4. Prednisone
    • Glucocorticoid - systemic
    • **use 1-2 weeks, chronic = life-threatening
    • Anti-inflammatory
    • Inhibition of leukotriene/prostaglandin synthesis
    • Regulation of inflammatory mediators
    • Regulation of norepinephrine and histamine
  5. Zafirlukast
    Leukotriene blocker, receptor antagonist
  6. Zileuton
    Leukotriene blockers, synthesis inhibitor
  7. Ipratropium
    • Antimuscarinic, muscarinic antagonist
    • Competitively inhibit bronchoconstriction produced by acetylcholine at muscarinic receptors
    • When co-administered with a beta agonist, leads to 10-15% further improvement
  8. Theophylline
    • Methylxanthine
    • antagonist at adenosine receptors
    • inhibitor of phosphodiesterase
  9. Omalizumab
    • Anti-IgE
    • antibody that binds to IgE
    • omalizumab bound IgE cannot activate mast cells
    • will not reverse bronchoconstriction

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