PTG 105-Exam 4-Muscles 3
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What type of cells are the anterior horn cells?
Nerve cells of the CNS
What type of paralysis do Poliomyelitis patients suffer from?
Describe the condition of a person with poliomyelitis:
- Flaccid paralysis of the arms and legs
- Difficulty breathing
What is ALS?
Amyotrophic lateral sclerosis
What is Amyotrophic lateral sclerosis?
Serious neurological disease that limits voluntary movement
How does Amyotrophic lateral sclerosis begin?
Muscle twitching/weakness in the arm/leg and slurring of speech
Is there a cure for Amyotrophic lateral sclerosis?
How long do people with Amyotrophic lateral sclerosis live usually?
3-5 years after first symptoms
Describe progressive stages of Amyotrophic lateral sclerosis:
- Inability to move muscles needed for eating, speaking, moving and breathing
- Last stages = difficulty breathing
Describe Myasthenia Gravis:
- AB destroy neuromuscular junctions
What is the presentation of Myasthenia Gravis?
Muscle weakness that increases during activity and improves during rest
What disease is marked by Muscle weakness that increases during activity and improves during rest?
Describe the immune that leads to Myasthenia Gravis:
- AB bind (and destroy) ACh receptors on skeletal muscle
- AutoABs seen in 90% of patients
Do all Myasthenia Gravis patients have autoantibodies?
No, but 90% do
What type of atrophy is seen with Myasthenia Gravis?
2/3 of Myasthenia Gravis patients have_______ and 15% have _______.
What What specific muscles are characteristically affected in Myasthenia Gravis?
- Causes drooping eyelids and double vision
Describe the presentation of Myasthenia Gravis:
- Drooping eyelids
- Double vision
- Slurred speech
- Diff. chewing, swallowing
- Some respiratory/general skeletal muscles maybe effected
What are the two types of treatment for Myasthenia Gravis?
- Increases Ach at neuromuscular junction
- Suppress production of abnormal Abs
For Myasthenia Gravis, In what ways can the production of abnormal ABs be thwarted?
What is Plasmapheresis?
What is Thyectomy?
Removal of the Thymus
What is the prognosis for pateints with Myasthenia Gravis?
Describe Polymyositis and Dermomyositis:
- Lymphocytic Inflammatory Autoimmune myopathies
- Cause symmetrical muscle weakness in large trunk, neck and limbs
What disease is a Lymphocytic inflammatory autoimmune myopathy that effects large muscles of the trunk, neck and extremities?
Dermatomyositis and Polymyositis
What type of inflammation is found in polymyositis and dermatomyositis?
What symptom does dermatomyositis have that polymyositis does not?
Rash on the upper eyelid
What inflammatory muscular disease has a rash on the upprer eyelid?
What symptoms of polymyositis and dermatomyositis be seen on a lab report?
- Lymphocytic inflammation of the muscle
- Antinuclear antibodies in the serum
- Elevated creatine kinase due to muscle injury
Are there lesions of the muscle tissue with dermatomyositis or polymyositis?
Inflammatory myopathies can be caused by dermatomyositis, polymyositis and what else?
- Viruses: HIV, Influenza
- Parasitic infections: Trichinosis, Cysticercosis, toxoplasmosis
HIV, Toxoplasmosis, Trichinosis, Cysticercosis and Influenza can all cause what disease?
What are the soft tissues?
What percent of soft tissue tomors are benign?
How do soft tissue tumors present?
As a Mass
At what age to soft tissue tumors present?
What is a malignant soft tissue tumor called?
What is a tumor of the adipose tissue called?
What is a tumor of the smooth muscle called?
What would you like to do?
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