PTG 105-Exam 4-Soft Tissue 3
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How common is Rhabdomyoma?
What other disease can rhabdomyoma occur with?
At what stage in life does Rhabdomyosarcoma occur?
Infancy through first decade
What is the most common sarcoma in children?
Children from 2-8 usually develop Rhabdomyosarcoma in what body areas?
Teenagers from 14-18 usually develop Rhabdomyosarcoma in what areas of the body?
What are the three subtypes of Rhabdomyosarcoma?
What characteristic indicates Aveolar Rhabdomyosarcoma?
Chromosomal translocation t(2, 13)
What disease typically shows chromostomal translocation t(2,13)
What are long thin cells associated with Rhabdomyosarcoma called?
What cells are often seen on a slide of Rhabdomyosarcoma?
What is the name for a benign smooth muscle tumor?
Where are Leiomyomas usually found?
- Sometimes subcutaneous
What is the most common neoplasm in women?
What is the histology of Leiomyoma?
- Blunt ended, elongated nuclei
- Minimal atypia
- Minimal mitosis
- No coagulative tumor necrosis
What type of tumor would you expect to have blunt ended, elongated nuclei, little atypia and mitosis and no coagulative necrosis factor?
What percent of adult soft tissue sarcomas are Leiomyosarcoma?
What sex is more likely to develop Leiomyosarcoma?
Where is a common site for metastasis of Leiomyosarcoma?
What are common sites for Leiomyosarcoma?
- Lumen of vessels (inferior vena cava, saphenous vein)
What would you expect to see on a slide of Leiomyosarcoma?
- High mitotic activity
- High pleomorphism
- Tumor cell necrosis
What is synovial sarcoma?
Deep seated tumor around large joints, usually in young adults
Where are most synovial sarcomas located?
80% at the knee or ankle
What age range is typical for synovial sarcoma?
How often does synovial sarcoma metastasize?
Where does synovial sarcoma metastasize to?
- Regional lymph nodes
What usually causes Synovial sarcoma?
Chromosomal translocation t(X;18), (p11.2; q11)
What percent of people with synovial sarcoma also have chromosomal translocation?
What is characteristic of the histology of synovial sarcoma?
- Spindle cells stroma and Round epithelial cells that form glands
What type of tumor has a biphasic histological appearance with spindle cells and round epithelial cells mixed as glands?
What are the important cell types of the epidermis?
- Squamous epithelial cells
What is another name for squamous epithelial cells of the epidermis?
What are the major components of the dermis?
- Blood vessels
- Hair follicles
- Sebaceous glands
- Sweat glands
Describe a Papule:
Elevated solid area (plaque)
What is an elevated solid area on the skin?
What is a Macule?
Flat area of coloration on the skin
What is the term for a flat area of coloration on the skin?
What is a Nodule?
A solid area larger than a papule
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