PHARM 5 - DIABETES

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Author:
dpaytons
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217945
Filename:
PHARM 5 - DIABETES
Updated:
2013-05-05 20:49:13
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pharm
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pharm 5
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  1. insulin lispro
    ultra short acting insulin prep, use before eating
  2. regular insulin
    short acting insulin prep
  3. NPH insulin
    intermediate acting insulin prep
  4. insulin glargine
    long acting insulin prep, manage throughout the day
  5. pramlintide
    • synthetic amylin
    • decreases gastric emptying, reduces glucagon secretion, supresses appetite
    • take before meals
  6. What do sulfonylureas do?
    • Insulin secretagogues
    • increase insulin release from the pancreas
  7. What do meglitinides do?
    • Insulin secretagogues
    • increase insulin release from the pancreas
  8. glyburide
    • 2nd generation sulfonylurea
    • take twice daily
    • increases insulin release from pancrease
    • Side effects: weight gain, hypoglycemia
  9. glimepiride
    • 3rd generation sulfonylurea
    • take once daily
    • increases insulin release from pancrease
    • Side effects: weight gain, hypoglycemia
  10. repaglinide
    • meglitinide
    • increases insulin release from the pancreas
    • short acting, take before meals
    • hypoglycemia
  11. What do biguanides do?
    Insulin sensitizers
  12. What do TZDs do?
    • Insulin sensitizers
    • PPAR-gamma
  13. metformin
    • biguanide
    • insulin sensitizer
    • AMP activated protein kinase
    • increased GLUT4 expression, increased insulin-independent glucose uptake, inhibits gluconeogenesis, decreased mobilization of free fatty acids, increased insulin sensitivity
    • WEIGHT LOSS, euglycemic
  14. rosiglitazone, trade name?
    Avandia
  15. rosiglitazone
    • TZD
    • insulin sensitizer
    • euglycemic, WEIGHT GAIN
    • increased coronary heart disease, stroke risk, bladder cancer, osteoporesis
  16. pioglitazone, trade name?
    Actos
  17. pioglitazone
    • TZD
    • insulin sensitizer
    • euglycemic, WEIGHT GAIN
    • increased coronary heart disease, stroke risk, bladder cancer, osteoporesis
  18. miglitol
    • alpha-glucosidase inhibitor
    • prevent breakdown and absorption of monosaccharides
    • use at mealtime
    • GI side effects (flatulence, diarrhea, cramps)
  19. exenatide
    • GLP-1 agonist
    • incretin related drug
    • peptide --> needs to be injected
  20. liraglutide
    • GLP-1 agonist
    • incretin related drug
    • peptide --> needs to be injected
  21. sitagliptin
    • DPP-4 inhibitor
    • incretin related drug
    • taken orally
    • inhibits the enzyme that breaks down incretins
  22. saxagliptin
    • DPP-4 inhibitor
    • incretin related drug
    • taken orally
    • inhibits the enzyme that breaks down incretins
  23. sitagliptin
    • DPP-4 inhibitor
    • incretin related drug
    • taken orally
    • inhibits the enzyme that breaks down incretins

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