med chem II ani-viral

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med chem II ani-viral
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2013-05-06 09:20:56
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med chem II ani-viral
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  1. approved for prophylactic use to reduce infection rates by HIV
    emtricitabine and tenofovir - truvada
  2. chemokine receptor 5 co-receptor antagonist used only in a CCR5-tropic HIV-1 detectable resistant strain
    maraviroc - selzentry
  3. most poorly tolerated of HIV protease inhibitors - severe diarrhea, flu-like symptoms, POTENT CYP 3A/2D6 inhibitor - capsules must be refrigerated
    ritonavir - norvir
  4. azapeptide inhibitor of HIV protease that is a potent inhibitor of glucuronidatoin by UGT1A1
    atazanavir - reyataz
  5. NNRTI with a black box warning against liver failure and > 40% develop Steven-Johnson syndrome
    nevirapine - viramune
  6. weakest NRTI - not used muck today
    zalcitabine - hivid
  7. HIV protease inhibitor - rapidly dissolving capsule that must be taken with a high fat food to ensure proper absorption - use 2 tsp. peanut butter
    nelfinavir - viracept
  8. NRTI drug also called azidothymidine (AZT) - anemia, neutropenia & initial therapy flu-like symptoms for weeks
    zidovudine - retrovir
  9. prophylactic vaccination against HPV type 16 & 18 that cause cervical cancers
    carvarix
  10. HIV drug use induced lipodystrophy treatment
    tesamorelin - EGRIFTA
  11. HAART treatment results in a severe inflammatory response to oppoortunisitc infective agents present which may need further treatment (ie TB,herpes, CMV)
    immune reconstitution syndrome
  12. NRTI with severe hypersensitivity that can be determined by pharmacogenomics testing for the HLA-B*5701 gene polymorphism
    abacavir  - ziagen
  13. NRTI indicated for pediatric use in patients over 3 months of age - not a CYP substrate/no inhibition of glucuronidation
    emtricitabine - emtriva
  14. HIV protease inhibitor that must be co-administered with 100 mg of ritonavir in order to inhibit CYP 3A/2D6 to ensure adequate plasma levels -
    darunavir ethanolate - prezista
  15. integrase strand inhibitor used in combo with any other NNRTI due to increase resistance potential
    raltegravir - isentress
  16. phosphate nucleotide analogue reverse transcriptase inhibitor with reduced activity against the K65R reverse transcriptase mutation (3% in USA)
    tenofovir - viread
  17. HIV protease inhibitor that is formulated with vitamin E - accordingly NO vitamin E supplementatoin
    amprenavir - agenerase
  18. HIV protease inhibitor with severe diet limitation; no food or low protein/fat food only - must remain hydrated to prevent kidney stones - dispense in manufacturer bottle only
    indinavir - crixivan
  19. BID subcutaneous injection that interfers with the binding of the GP41 subunit of the viral envelope with the host cell cellular membrae preventing fusion
    enfuvirtide - fuzeon
  20. NNRTI agent - DO NOT use in combo with any other NNRTI due to increase resistance potential
    rilpivirine - endurant

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