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kyleannkelsey
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What geographical areas is Trypanosoma brucei found in?
Central Africa only
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What is the pathogenesis of T. brucei?
- Multiplies at the wound
- Travels through the blood
- Enters the CNS
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Where does T. brucei multiply at?
The wound
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Describe the symptoms of African Sleeping sickness:
- Progressive nervous system disorder
- Recurrent fever
- Tender lymph nodes
- headache
- impaired thinking/behavior/brain activity
- Tremors, seizures, paralysis, coma
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If untreated, what is the outcome of T. brucei infections?
100% fatal
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What does trypasnosoma cruzi cause?
Chagas' Disease/American trypanosomiasis
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What causes Chagas' Disease/American Trypanosomiasis?
Trypanosoma cruzi
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What is the infection rate of Trypanosoma cruzi in south and central america?
15-20 million
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What is the death rate due to Trypanosoma cruzi every year?
50,000, mostly children
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How many people are infected with Trypanosoma cruzi right now in the U.S.?
300,000
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How is Trypanosoma cruzi transmitted?
Reduviid bug (kissing big)
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What disease is transmitted by the kissing bug/Reduviid bug?
American Trypanosomiasis or Chagas' Disease
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When and Where on the body are most people bitten by the kissing bug?
- Night
- Around the mouth and face
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Describe the chronic phase of Chagas' disease?
Immunity to re-infection but parasite is not eliminated
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What percent of Chronic Chagas' infections are asymptomatic?
41%
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What percent of Chronic Chagas' infections lead to cardiomyopathy?
45%
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What percent of Chronic Chagas' infections lead to Megaesophogus?
11%
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What percent of Chronic Chagas' infections lead to Megacolon?
3%
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What are the potential outcomes of Chronic Chagas' infections?
- Asymptomatic
- Cardiomyopathy
- Megacolon
- Megaesophogus
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What area of the body does Trypanosoma cruzi not enter?
Nervous tissue
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What percent of untreated Trypanosoma cruzi patients die?
5-10%
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What is the general outcome of Chagas' Disease?
Widespread tissue and heart damage
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What is the treatment for Trypanosoma cruzi infection?
- Nifurtimox
- Allopurinol
- Benznidazole
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What would you treat with Benznidazole, Allopurinol or Nifurtimox?
Trypanosoma cruzi
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What group usually develops chronic heart issue with Chagas'?
Children, heart failure 20 years later
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