Card Set Information
More than __ hormones identified in humans.
Many hormones require __; __ do not
Steroid Hormones and Gene Expression
Pass through target cell membrane and bind to a receptor protein in
- Hormone receptor complex binds to specific sites (acceptor protein) along chromatin to activate gene expression.
- Two cell types can respond differently to same steroid hormone since acceptor proteins associated with different genes
Peptide Hormones And Hormones Derived From Amino Acids
Work By __
What are they?
Cyclic AMP (cAMP)
- what it stands for?
- what that does
- synthesized from ATP by
- activates protein
target proteins producing cellular response.
What is the g-protein pathway if epinephrine initiates the signal?
Epinephrine binds to G protein- coupled receptor, causing G protein to convert GTP to ATP and also activate adenylyl cyclase.
Adenylyl cyclase will convert ATP to cAMP, which activatse protein Kinase A and causes a response.
Membrane Lipid System (__)
IP3 and DAG
- DAG (
What is the cascade, part 1 and 2?
present in inner membrane.
- PI phosphorylated to (2-steps) to phosphatidylinositol-4,5-
What is the cascade, parts 3 and 4?
PIP2 cleaved by
C to produce IP3 and DAG (Note
C activation is G-protein mediated)
- IP3 water soluble, diffuses into cytoplasm, binds to receptors on ER stimulates release of Ca2+.
What is the cascade, parts 5 and 6?
- DAG activates Protein