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What are the factors of susceptibility to viruses?
- Number of receptors
- ability of host to support virus
What type of measurement is Susceptibility?
What is the purpose of a capsid?
To stabilize and protect the genome
What type of environmental variations are capsids meant to protect against?
What viral structure protects against Temperature, pH and chemical composition of the environment?
What is another word for the viral Nucleocapsid?
What forms the substructure of a viral particle?
Describe an icosahedral viral shape:
- 520 triangular surfaces
- 2,3, and 5 fold axes of symmetry
What type of virus has a Helical formation, as described in class?
Tobacco mosaic viruses
What is an example of an ovoid virus?
Describe a Helical formation of a virus?
What is a variation of the icosahedrical viral shape?
Describe the composition of viral envelope:
Lipid bilayer with glycoproteins
Where does the viral envelope reside?
What are the advantages of a viral envelope?
Protects against chemicals and enzymes
What are the disadvantages of a viral envelope?
Less stable in the environment
How do viruses acquire membranes?
By budding out of host
What host membranes are viral membranes derived from?
- Plasma membrane
- Nuclear membrane
Viral envelope proteins are post-translationally targeted to what?
The appropriate membrane
How (generally) do viruses replicate?
- Fusion and host cell entry
What is the first step in Viral replication?
- Viral binding to host cell
- What is require for viral host cell binding?
- Specific host cell receptors-protein