MIC 541-Exam 5-Virology 3
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What limits host cell range and susceptibility?
Protein receptors for viral binding
What step occurs after viral binding to receptors on the host?
- Fusion with plasma membrane
- Penetration through plasma membrane
Describe the process of viral fusion:
- Fusion entry
- Receptor binding cause conformation change in envelope and fusion to host plasma membrane
What type of viruses fenter the cell by fusion?
How do enveloped viruese enter the cell?
Describe viral endocytosis:
- Virus enters in an endosome (enveloped in host membrane)
- pH changes cause viral fusion/release from endosome into the cytosol
What type of viruses penetrate the plasma membrane without fusion or endocytosis?
How do non-enveloped viruses enter the host cell?
Penetration through plasma membrane
What type of viruses enter the cell in a membrane?
- Those that enter via endocytosis
What type of viruses do not enter the hose cell in a membrane?
Is viral uncoating well understood?
What initiates uncoating of a virus?
- Cellular signals:
- pH change
- Receptor binding
What type of uncoating occur?
What type of virus uses partial uncoating?
Those that use the coat in the formation of the viral replication complex
What can the coat be used for?
viral replication complex
Where does replication of RNA viruses occur?
In the cytoplasm
What may aid RNA viral replication?
Viral replication complexes
What molecule is involved in RNA viral replication?
What is needed for synthesis of viral proteins?
Relies on host machinery
Where does replication of DNA viruses occur?
In the nucleus
What molecule is required for replication of viral DNA?
What would you like to do?
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