MIC 541-Exam 5-Virology 4

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MIC 541-Exam 5-Virology 4
2013-05-07 19:06:55
MIC 541 Exam Virology

MIC 541-Exam 5-Virology 4
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  1. Do DNA viruses need host machinery for replication?
    Depends on the virus (Yes and No)
  2. For enveloped viruses, where does assembly take place?
    At the site of envelope acquisition (nucleus, golgi, etc.)
  3. where does core assembly occur for DNA viruses?
    In the Nucleus
  4. Where does core assembly occur for RNA viruses?
    The cytoplasm
  5. What are the three ways viruses are released from the host cell:
    • Lytic
    • Exocytosis
    • Budding
  6. Describe lytic release of viruses:
    • Critical mass is achieved by particle accumulation
    • Viral signal induce cell death and virion release
  7. Describe exocytosis of virions from the host cell:
    Via normal cellular pathways
  8. When does viral maturation occur:
    during or after budding /release
  9. What is the signal for matureation of viruses?
    Not known
  10. Where do most DNA cell bud off?
    The nucleus
  11. What level of disease is caused by most viruses?
    No disease at all
  12. What are zoonoses?
    Viruses that infect many animals
  13. What are the most common manifestations of viruses:
    • Rashes
    • Fever
    • Muscle aches
    • Respiratory symptoms
    • Swollen lymph nodes
  14. What type of infections are associated with RNA viruses?
    Acute infection
  15. What RNA viruses are not associated with acute infections?
    • Hep C
    • Retroviruses
  16. What are the general body defenses to viruses?
    • interferon
    • Antibodies
    • Cytotoxic T cells
  17. What type of immunity is usually acquired after contact with viruses?
    Lifetime immunity
  18. What is the most common viral infection course?
    Rapid lytic course
  19. How long can some viruses last in the host:
    Chronic infections of years to a lifetime
  20. What are the two types of persistent viral infections?
    • Chronic infections
    • Latent infections
  21. What are chronic viral infections like?
    • Virus is detectable in tissue samples
    • multiplies at slow rates
    • mild or absent symptoms
  22. What type of persistent viral infection is detectable in tissues, multiplies slowly and has mild or absent symptoms?