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Describe a latent viral infection:
- Lytic cycle
- Virus then enter dormant phase
- none detectable in tissues
- no symptoms
- Can reactivate
What type of persistent viral infection has a lytic stage followed by dormancy that can reoccur. During dormancy the virus cannot be detected in the tissues and there are no symptoms?
Can viruses change cells oncolytically?
What viruses have oncolytic abilities in the host?
- Hep B
- Human T-cell leukemia virus
What ability is found with Epstein-Barr virus, Hep B, Papillomavirus and HumanT-cell leukemia virus?
Oncolytic transformation of host cell
How are viral disease diagnosed?
- Clinical signs
What is a common serological test for anti-viral antibodies?
What type of test is an ELISA?
Serological-tests for anti-viral antibodies in the serum
How is PCR used to detect Viruses?
Primers are used to detect nucleic acids of viruses in blood, mucus and tissues
What type of culture is needed to grow viruses?
What are the best targets for viral treatments?
- unique viral enzymes:
- Viral polymerases
- proton pumps
- HIV-1 reverse transcriptase
What type of viral drug is an immune modulating drug?
What is Ribavirin?
Synthetic nucleoside analog of guanosine
What is a synthetic nucleoside analog og guanosine used to treat viral infections?
What is Ribavirin approved for?
- RSV= respiratory syncytial virus
- Hep C (with alpha-interferon)
What is approved for treatment of respiratory syncytial virus and Hep C?
What must Ribavirin be used in combination with to treat Hep C?
What does Ribavirin have activity against in vitro?
- Wide range of DNA and RNA viruses