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What are recurrent bouts of HSV-2 triggered by?
- concurrent bacterial infection
What HSV type can be triggered by menstruation?
Where is Latency of HSV-2 imparted from?
What are the symptoms of early Herpes genitalia?
- Bilateral swelling/tenderness in groin
What are the eventual (not early) symptoms of HSV-2?
- Cluster of sensitive vesicles on genitalia, perineum and buttocks
- painful urination
- vesicles ulcerate
What type of herpes can be found in newborns?
HSV-1 and II
Is HSV in newborns a concern?
Yes can be fatal to neonates or fetuses
How can a neonate acquire HSV?
- During birth
- hand transmission after birth
What areas of the body do neonates show HSV infections?
How are HSV infections prevented in neonates?
- preventative screening of pregnant women
- C-section delivery if current out-break
What type of HSV infection can be caused by both HSV-1 and 2?
Where are the lesions of herpetic whitlow usually located?
Describe the lesions of herpetic whitlow:
- Skin penetrating
- one finger
- extremely painful and itchy
What is the most common sporadic form of viral encephalitis in the U.S.?
Is HSV-1 encephalitis common?
People with underlying immunodeficiencies are prone to what type of HSV infection?
What is a very severe form of Herpes that is acquired by immunodeficient patients?
How is Herpes diagnosed?
- Vesicle and exudates examination
- Scrapings from base of lesions show Giant cells
- Culture or specific tests for disseminated HSV
- Direct fluorescent antibody tests
What drugs are available for Herpes Simplex infections?
- Valacyclovir (L-valyl ester of acyclovir)
- Topical Medications
How is Acyclovir activated?
By TK = thymidine kinase enzyme
What is the action of Acyclovir?
- Inhibits HSV viral polymerase
- dGTP competitor
- Causes DNA chain termination