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What virus causes Giant cells with nuclear and cytoplasmic inclusions?
What are the common symptoms for Cytomegalovirus?
What symptoms of Cytomegalovirus are seen in newborns?
- Enlarged liver and spleen
- Capillary bleeding
- ocular inflammation
babies that survive Cytomegaloviral infections have what prolonged symptoms?
- Neurological sequelae
- Hearing and visual disturbances
- Mental retardation
Perinatal CMV infections have what symptoms?
- mononeucleosis like syndrome
What does CMV cause in AIDS patients?
- CMV mononucleosis
- Disseminated CMV
What can CMV cause in transplant patients?
What treatment for CMV is given to the immunocomprimised?
- Ganciclovir (Acyclovir analog)
What is Ganciclovir?
Acyclovir analog that is more effective against CMV
What is Foscarnet?
- non-nucleoside inhibitor of viral DNA polymerase
- Used to treat CMV
What part of the body does EBV infect?
Lymphoid tissue and Salivary glands
Where is EBV found in the environment?
What is the route of transmission for EBV?
- Direct oral contact
- Contamination with saliva
What does EBV cause?
What group is susceptible to EBV in industrialized countries?
College aged population
By mid-life, what percent of people have gotten EBV?
What are the symptoms of infectious mononucleosis?
- Sore throat
- High fever
- Cervical Lymphadenopathy
What is the incubation period for infectious mononucleosis?
Can EBV be reactivated?
Yes, usually less severe
Where does EBV lay dormant?
What virus lays dormant in the B cells?
What are the complications of EBV?
- Burkitt lymphoma
- Nasopharyngeal carcinoma