MIC 541-Exam 5-Virology 15
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What virus can lead to Burkitt lymphoma and Nasopharyngeal carcinoma?
What is Burkitt lymphoma?
- B cell malignancy
- Usually develops in the jaw
What group is most susceptible to EBV induced Burkitt lymphoma?
4-8 year old Central African children
Other than EBV, Burkitt lymphoma is associated with what disease?
Recurrent Malaria infections
How does Burkitt lymphoma present?
As a swelling in the cheek
What is nasopharyngeal carcinoma?
Malignancy of epithelial cells
What group is most likely to get EBV induced nasopharyngeal carcinoma?
Chinese and African men
How is EBV diagnosed?
- Serological assays detect antibodies and antigen
- Also find:
- Large atypical lymphocytes
What is the treatment for normal infections of EBV?
Usually symptom relief for fever and sore throat
What type of treatment is recommended for Disseminated EBV?
- IV gamma globulin
- monoclonal antibodies
What was the original name for HHV-6
What is the route of transmission for HHV-6?
Saliva or secretion contact
What disease does HHV-6 cause?
What is Roseola?
- HHV-6 disease
- Acute febrile disease in babies 2-12 months
Describe the symptoms of HHV-6:
- Faint macropapular rash
How is Roseola treated?
What group is Roseola foundin?
Babies 2-12 months
What infection can adults get from HHV-1?
- Mono-like symptoms
What Herpes virus has a high seroprevalence?
What virus is found in 70% of MS patients?
What percent of MS patients are found to have HHV-6 infections?
What serious diseases is HHV-6 connected to?
- Hodgkin's lymphoma
- oral carcinoma
- T-cell leukemias
What virus is associated with T-cell Leukemias, MS, Hodgkin's lymphoma and oral cancer?
Describe HHV-7 characteristics?
Very similar to HHV-6 in diseases caused
What disease is associated with HHV-8?
- Karposi sarcoma
- Multiple myeloma
What Herpes virus is implicated in Karposi's sarcoma and Multiple myeloma?
What is a common AIDS tumor that is linked to HHV-8?
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