MIC 541-Exam 5-Virology 17

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kyleannkelsey
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MIC 541-Exam 5-Virology 17
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2013-05-08 00:38:52
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MIC 541 Exam Virology 17
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MIC 541-Exam 5-Virology 17
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  1. What is the action during the HBV lifecycle?
    • Enters the cell as DNA
    • Produces RNA in the nucleus
    • Turns RNA to DNA (reverse transcription)
    • Packages DNA into viral capsids
  2. What is the disease action of HBV?
    Multiplies in the liver and continually seed the blood with virions
  3. How many virions are found in the blood of HBV infected patients?
    10^7 virions/mL of blood
  4. How much blood does it take to infect someone with HBV?
    Minute amounts because there are so many virions in the blood
  5. What groups have a particularly high incidence of HBV?
    • Homosexuals
    • Drug addicts
  6. Can HBV become Chronic?
    Yes
  7. What doe HBV increase the risk of?
    Liver cancer = hepatocellular carcinoma
  8. What are the clinical features of HBV?
    • Rash
    • Enlarged liver
    • abdominal pain
    • Arthritis
    • Low white blood cell count
    • Fever
  9. A person that presents with a rash on the chest, arthritis, an enlarged liver, abdominal pain, Low WBC count and a fever, likely has what disease?
    HBV infection
  10. How is HBV transmitted?
    • Through a break in the skin or mucus membrane
    • injection into Blood
  11. What happens to most patients infected with HBV?
    • few overt symptoms
    • Eventually develop HBV immunity
  12. What HBV symtpoms are considered severe?
    • Fever
    • jaundice
    • rash
    • arthritis
  13. What HBV symptoms are normal and not severe?
    • malaise
    • fever
    • chills
    • anorexia
    • abdominal discomfort
    • diarrhea
  14. What percent of HBV infected individuals develop acute liver failue?
    <1%
  15. What proportion of HBV infected individuals develop necrosis or cirrhosis?
    Small number
  16. What is used to diagnose HBV?
    • examination of risk factors
    • Serological tests = radioimmunoassay and ELISA
  17. HBV screening id necessary for what?
    • Blood transfusion
    • Semen at sperm banks
    • organs for transplant
    • routine prenatal testing
  18. What are chronic HBV infections treated with?
    Interferon alpha or pegylated interferon
  19. What are mild cases of HBV treated with?
    Symptom support only
  20. What is the treatment for people that may have been exposed to HBV, including neonates born to infected mothers?
    Immunoprophylaxis with Anti-HB immunoglobulin
  21. What is the primary form of prevention for HBV?
    vaccination for high risk individuals and newborns
  22. What are nucleoside analogs that are used to treat HBV?
    • Lamivudine
    • abacavir
    • tenofovir
    • Telbivudine
    • Entecavir
  23. What is entecavir?
    Deoxyguanosine analog used in HBV treatments
  24. What is Telbivudine?
    Thymidine analog used to treat HBV
  25. What is Lamivudine, abacavir and tenofovir?
    • HIV reverse transcriptase inhibitors
    • Nucleoside analog
  26. What type of virus is the Adenovirus?
    • Non-enveloped
    • Double-stranded DNA
  27. What body areas are infected by adenovirus?
    • Lymphoid tissue
    • respiratory tissue
    • intestinal epithelia
    • Conjunctiva
  28. What diseases does Adenovirus cause?
    • Colds
    • pharyngitis
    • conjunctivits
    • keratoconjunctivits
    • acute hemorrhagic cystitis
  29. What virus group causes colds, pharyngitis, conjunctivitis, keratoconjunctivitis and acute hemorrhagic cystitis?
    Adenovirus

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