MIC 541-Exam 5-Virology 20

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MIC 541-Exam 5-Virology 20
2013-05-08 03:02:18
MIC 541 Exam Virology 20

MIC 541-Exam 5-Virology 20
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  1. How Flaviviruses classified?
    • Non-segmented
    • Single stranded
    • Enveloped
    • RNA virus
  2. What is an important part of the HCV genome for viral replication?
  3. What does NS3/4A code for?
    • Serine protease required for cleavage of polyprotein
    • Critical for RNA replication and virion assembly
  4. What is NS3/4A specifically?
  5. What type of virus is HCV?
  6. What percent of the world population is infected with HCV?
    2-3% (170 million people)
  7. How is HCv acquired?
    • Blood contact
    • Transfusions/needles
  8. Are there strict symptoms associated with HCV?
    No, varying characteristics
  9. What percent of HCV infected individuals remain infected indefinitely?
  10. What is more common with HCV, severe symptoms with no liver disease or liver disease with no symptoms?
    Liver disease with no symptoms
  11. What percent of HCV infected individuals have clinical symptoms at 15 years after infection?
  12. How long does it take for HCV to lead to cirrhosis?
    20 years
  13. When does cancer usually result from a chronic HCV infection?
    25 years after infection
  14. What are the risk factors for HCV infections?
    • Illicit drug use
    • blood transfusion
    • Surgery abroad
    • Haemodialysis
    • Needlestick injury
    • Sexual promiscuity
    • Tatooing/Body peircing
    • Mother
  15. What is the HCV course?
    • Acute infection
    • Chronic infection
    • Chronic hepatitis
    • Cirrhosis
    • Hepatocellular carcinoma
  16. What important advancement for HCV was made in 2011?
    NS3/4A protease inhibitors approved
  17. What advancement in HCV treatment was made in 2005?
    production of recombinant infectious HCV in tissue culture
  18. When were ribavirin and interferon-alpha introduced?
  19. When was HCV identiifed?
  20. What is the treatment for HCV?
    • Pegylated interferon and ribavirin
    • OR
    • Boceprevir and Telaprevir
  21. What is the efficacy in Pegylated interferon and ribavirin treatment for HCV?
    40-50% efficacy
  22. What is the efficacy of Boceprevir and Telaprevir with iterferon/ribavirin for HCV treatment?
  23. What is the action of Boceprevir and Telaprevir?
    NS3/4A protease inhibitor
  24. The Boceprevir/Telaprevir/interferon/ribavirin combination therapy has a higher efficacy and what other benefit?
    shortened treatment time
  25. What genotype is susceptible to Boceprevir/Telaprevir/interferon/ribavirin combination?
    Genotype I
  26. What is Boceprevir/Telaprevir/interferon/ribavirin combination side effects?
    • Flu like symptoms
    • Sleep
    • Disturbances
    • emotional problems
  27. What are arboviruses?
    Viruses spread by arthropods