MIC 541-Exam 5-Virology 20
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How Flaviviruses classified?
- Single stranded
- RNA virus
What is an important part of the HCV genome for viral replication?
What does NS3/4A code for?
- Serine protease required for cleavage of polyprotein
- Critical for RNA replication and virion assembly
What is NS3/4A specifically?
What type of virus is HCV?
What percent of the world population is infected with HCV?
2-3% (170 million people)
How is HCv acquired?
- Blood contact
Are there strict symptoms associated with HCV?
No, varying characteristics
What percent of HCV infected individuals remain infected indefinitely?
What is more common with HCV, severe symptoms with no liver disease or liver disease with no symptoms?
Liver disease with no symptoms
What percent of HCV infected individuals have clinical symptoms at 15 years after infection?
How long does it take for HCV to lead to cirrhosis?
When does cancer usually result from a chronic HCV infection?
25 years after infection
What are the risk factors for HCV infections?
- Illicit drug use
- blood transfusion
- Surgery abroad
- Needlestick injury
- Sexual promiscuity
- Tatooing/Body peircing
What is the HCV course?
- Acute infection
- Chronic infection
- Chronic hepatitis
- Hepatocellular carcinoma
What important advancement for HCV was made in 2011?
NS3/4A protease inhibitors approved
What advancement in HCV treatment was made in 2005?
production of recombinant infectious HCV in tissue culture
When were ribavirin and interferon-alpha introduced?
When was HCV identiifed?
What is the treatment for HCV?
- Pegylated interferon and ribavirin
- Boceprevir and Telaprevir
What is the efficacy in Pegylated interferon and ribavirin treatment for HCV?
What is the efficacy of Boceprevir and Telaprevir with iterferon/ribavirin for HCV treatment?
What is the action of Boceprevir and Telaprevir?
NS3/4A protease inhibitor
The Boceprevir/Telaprevir/interferon/ribavirin combination therapy has a higher efficacy and what other benefit?
shortened treatment time
What genotype is susceptible to Boceprevir/Telaprevir/interferon/ribavirin combination?
What is Boceprevir/Telaprevir/interferon/ribavirin combination side effects?
- Flu like symptoms
- emotional problems
What are arboviruses?
Viruses spread by arthropods
What would you like to do?
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