MIC 541-Exam 5-Mycology 11
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What is the dose limiting factor for Amphotericin B?
What type of Amphotericin B has a lower renal toxicity?
Liposome or lipid complex versions
What are the advantages of Liposome or lipid complex Amphotericin Bs?
Lower renal toxicity
Are lipid complexed/liposome Amphotericin Bs more effective than the normal kind?
What are the type of liposome or lipid complexed Amphotericin Bs?
What are Amphotec, Abelcet and AmBisome?
Liposome or lipid complexed Amphotericin Bs
What is Nystatin similar to?
What type of drug is Nystatin?
How is Nystatin administered?
- Rarely used systemically
What is Nystatin used for?
- Candida infections
- Cutaneous dermatophytes
What type of drug is 5-Flourocytosine?
What antifungal drug is a Pyrimidine?
What type of infections are treated with 5-flourcytosine?
How is 5-flourocytosine administered?
How does 5-flourcytosime work?
- Fungi use it via permease that humans don’t make
- Causes translation misreads and mistakes
Can 5-fourocytosine enter the CNS?
Why is 5-flourocytosine no tused alone?
What is 5-flourocytosine administered with?
Why not just use Amphotericin B rather than a mix of Amphotericin B and 5-flourocytosine?
5-flourocytosine reduces the amount of Amphotericin B needed
What are the side effects of 5-flourocytosine?
- Bone marrow suppression
- Hair loss
What is the dose limiting factor for 5-flourocytosine?
Bone marrow suppression
What causes hair loss in people receiving 5-flourcytosine?
5-flourouracil release from dying fungi
Is hair loss associated with 5-flourocytosine permanent?
What is another term for Lamisil?
What is another term for Terbinafine?
What type of drug is Terbinafine/Lamisil?
What is the action of terbinafine?
- Interferes with ergosterol synthesis by blocking squalene epoxidase enzyme
- Fungi then cant form membranes properly
How is Terbinafine administered?
- Mostly topical
- Some oral routes
What is Terbinafine mostly used for?
- Especially nail infections
What are the common side effects of Terbinafine?
Side effects are uncommon
What is the major class of antifungal drugs?
What is the action of Azoles?
- Cytochrome inhibition
- Prevents ergosterol formation
- Disrupts membrane function and growth
What are the major groups of Azoles?
What is the active component of Imidazoles?
The imidazole ring
What is the action of the imidazole ring?
- Blocks action of cytochrome P450
- Inhibits ergosterol synthesis
What are two examples of imidazoles?
What is oral ketoconazole used for?
- Some systemic
What is Clotrimazole and Miconazole used for?
Topical replacement for Nystatin
What is another name for Clotrimazole?
What is another name of lotrimin?
What would you like to do?
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