MIC 541-Exam 5-Mycology 11

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kyleannkelsey
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MIC 541-Exam 5-Mycology 11
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2013-05-08 10:54:59
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MIC 541 Exam Mycology 11
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MIC 541-Exam 5-Mycology 11
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  1. What is the dose limiting factor for Amphotericin B?
    Renal toxicity
  2. What type of Amphotericin B has a lower renal toxicity?
    Liposome or lipid complex versions
  3. What are the advantages of Liposome or lipid complex Amphotericin Bs?
    Lower renal toxicity
  4. Are lipid complexed/liposome Amphotericin Bs more effective than the normal kind?
    No
  5. What are the type of liposome or lipid complexed Amphotericin Bs?
    • AmBisome
    • Abelcet
    • Amphotec
  6. What are Amphotec, Abelcet and AmBisome?
    Liposome or lipid complexed Amphotericin Bs
  7. What is Nystatin similar to?
    Amphotericin Bs
  8. What type of drug is Nystatin?
    Polyene
  9. How is Nystatin administered?
    • Topically
    • Rarely used systemically
  10. What is Nystatin used for?
    • Candida infections
    • Thrush
    • Cutaneous dermatophytes
  11. What type of drug is 5-Flourocytosine?
    Pyrimadine
  12. What antifungal drug is a Pyrimidine?
    5-flourocytosine
  13. What type of infections are treated with 5-flourcytosine?
    Systemic
  14. How is 5-flourocytosine administered?
    Orally
  15. How does 5-flourcytosime work?
    • Fungi use it via permease that humans don’t make
    • Causes translation misreads and mistakes
  16. Can 5-fourocytosine enter the CNS?
    Yes
  17. Why is 5-flourocytosine no tused alone?
    Resistance development
  18. What is 5-flourocytosine administered with?
    Amphotericin B
  19. Why not just use Amphotericin B rather than a mix of Amphotericin B and 5-flourocytosine?
    5-flourocytosine reduces the amount of Amphotericin B needed
  20. What are the side effects of 5-flourocytosine?
    • Bone marrow suppression
    • Hair loss
  21. What is the dose limiting factor for 5-flourocytosine?
    Bone marrow suppression
  22. What causes hair loss in people receiving 5-flourcytosine?
    5-flourouracil release from dying fungi
  23. Is hair loss associated with 5-flourocytosine permanent?
    No, temporary
  24. What is another term for Lamisil?
    Terbinafine
  25. What is another term for Terbinafine?
    Lamasil
  26. What type of drug is Terbinafine/Lamisil?
    Allylamine
  27. What is the action of terbinafine?
    • Interferes with ergosterol synthesis by blocking squalene epoxidase enzyme
    • Fungi then cant form membranes properly
  28. How is Terbinafine administered?
    • Mostly topical
    • Some oral routes
  29. What is Terbinafine mostly used for?
    • Dermatophytes
    • Especially nail infections
  30. What are the common side effects of Terbinafine?
    Side effects are uncommon
  31. What is the major class of antifungal drugs?
    Azoles
  32. What is the action of Azoles?
    • Cytochrome inhibition
    • Prevents ergosterol formation
    • Disrupts membrane function and growth
  33. What are the major groups of Azoles?
    • Imidazoles
    • Triazoles
  34. What is the active component of Imidazoles?
    The imidazole ring
  35. What is the action of the imidazole ring?
    • Blocks action of cytochrome P450
    • Inhibits ergosterol synthesis
  36. What are two examples of imidazoles?
    • Clotrimazole
    • Miconazole
    • Ketoconazole
  37. What is oral ketoconazole used for?
    • Dermatophytes
    • Candida
    • Some systemic
  38. What is Clotrimazole and Miconazole used for?
    Topical replacement for Nystatin
  39. What is another name for Clotrimazole?
    Lotrimin
  40. What is another name of lotrimin?
    Clotrimazole

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