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MIC 541-Exam 5-Mycology 11
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What is the dose limiting factor for Amphotericin B?
Renal toxicity
What type of Amphotericin B has a lower renal toxicity?
Liposome or lipid complex versions
What are the advantages of Liposome or lipid complex Amphotericin Bs?
Lower renal toxicity
Are lipid complexed/liposome Amphotericin Bs more effective than the normal kind?
No
What are the type of liposome or lipid complexed Amphotericin Bs?
AmBisome
Abelcet
Amphotec
What are Amphotec, Abelcet and AmBisome?
Liposome or lipid complexed Amphotericin Bs
What is Nystatin similar to?
Amphotericin Bs
What type of drug is Nystatin?
Polyene
How is Nystatin administered?
Topically
Rarely used systemically
What is Nystatin used for?
Candida infections
Thrush
Cutaneous dermatophytes
What type of drug is 5-Flourocytosine?
Pyrimadine
What antifungal drug is a Pyrimidine?
5-flourocytosine
What type of infections are treated with 5-flourcytosine?
Systemic
How is 5-flourocytosine administered?
Orally
How does 5-flourcytosime work?
Fungi use it via permease that humans don’t make
Causes translation misreads and mistakes
Can 5-fourocytosine enter the CNS?
Yes
Why is 5-flourocytosine no tused alone?
Resistance development
What is 5-flourocytosine administered with?
Amphotericin B
Why not just use Amphotericin B rather than a mix of Amphotericin B and 5-flourocytosine?
5-flourocytosine reduces the amount of Amphotericin B needed
What are the side effects of 5-flourocytosine?
Bone marrow suppression
Hair loss
What is the dose limiting factor for 5-flourocytosine?
Bone marrow suppression
What causes hair loss in people receiving 5-flourcytosine?
5-flourouracil release from dying fungi
Is hair loss associated with 5-flourocytosine permanent?
No, temporary
What is another term for Lamisil?
Terbinafine
What is another term for Terbinafine?
Lamasil
What type of drug is Terbinafine/Lamisil?
Allylamine
What is the action of terbinafine?
Interferes with ergosterol synthesis by blocking squalene epoxidase enzyme
Fungi then cant form membranes properly
How is Terbinafine administered?
Mostly topical
Some oral routes
What is Terbinafine mostly used for?
Dermatophytes
Especially nail infections
What are the common side effects of Terbinafine?
Side effects are uncommon
What is the major class of antifungal drugs?
Azoles
What is the action of Azoles?
Cytochrome inhibition
Prevents ergosterol formation
Disrupts membrane function and growth
What are the major groups of Azoles?
Imidazoles
Triazoles
What is the active component of Imidazoles?
The imidazole ring
What is the action of the imidazole ring?
Blocks action of cytochrome P450
Inhibits ergosterol synthesis
What are two examples of imidazoles?
Clotrimazole
Miconazole
Ketoconazole
What is oral ketoconazole used for?
Dermatophytes
Candida
Some systemic
What is Clotrimazole and Miconazole used for?
Topical replacement for Nystatin
What is another name for Clotrimazole?
Lotrimin
What is another name of lotrimin?
Clotrimazole
Author
kyleannkelsey
ID
218549
Card Set
MIC 541-Exam 5-Mycology 11
Description
MIC 541-Exam 5-Mycology 11
Updated
5/8/2013, 2:54:59 PM
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