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Normocytic anemia - give MCV range
80 - 100
Time it takes for reticulocyte to become mature RBC
Time it takes for bone marrow to respond by making more reticulocytes
Correcting reticulocyte count for anema - give the equation
What is an increased reticulocyte count?
(Hct / 45) x reticulocyte ct
e.g. if Hct is 15% and reticulocyte ct is 9% -> corrected retic count is 3%
less than 3% is bad response
Stain used to see black RNA filaments in reticulocyte
What do these imply?
reticulocyte is still synthesizing Hb
How long until polychromasia reticulocytes mature to RBC?
What correction do you make to reticulocyte count if polychromasia is present?
divide by 2
Numerical relationship between Hct and Hb
For every unit of tranfused packed RBCs, how much does Hb and Hct increase by?
Most common cause of anemia worldwide?
Hct / 3 = Hb
e.g. if Hct is 15% -> Hb is 5
for every unit transfused, Hb increases by 1 and Hct increases by 3%
e.g. pt w/ 5g of Hb, given 3 units of packed RBCs. The following day Hb is 6g and Hct is 18g. Is this an appropriate response? No, should've been Hb 8 and Hct 24. Pt had GI bleed.
- Most common cause of anemia: Fe deficiency
- Most common cause of Fe def: GI bleed
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