Neural Development

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Author:
lyncho87
ID:
219868
Filename:
Neural Development
Updated:
2013-05-15 23:23:47
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NUPT
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NUPT neural development
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  1. Neural Plate
    Develops into the nervous system. Eventually forms the neural groove and the neural fold.Appears at the 3rd week.
  2. Neural folds
    Form from the neural plate within 20 days, become elevated and the ends fuse together forming the neural tube. The tube later forms the brain (rostral portion) and spinal cord (caudal portion).
  3. Neurulation
    Formation of the neural tube
  4. Spina bifida occulta
    Less serious form, the vertebral arch doesn't close--does not affect meninges, or cause deficits
  5. Myelomeningocele
    Most common and serious form of spina bifida cystica- vertebral column lengthens and pulls on the cerebrum cutting off flow of CSF and causing hydrocephalus
  6. Lipomeningocele
    Also known as a lipoma or lipocele- fatty tissue that can occur in spina bifida- extends thru the dura
  7. Encephalocele
    Failure of the rostral neural tube to close- meninges can project thru the defect with our without brain matter. Causes motor, sensory and cognitive defects
  8. Anencephaly
    Failure of neurocranium and brain to develop. Most common cause for stillborn births.
  9. Prosencephalon
    • Forebrain
    • Differentiates in week 5 into the telencephalon (later becoming the hemispheres) and the diencephalon (becoming the thalamus, subthalamus, hypothalamus, and retina)
  10. Mesencephalon
    Midbrain- remains undivided
  11. Rhombencephalon
    • Hindbrain
    • splits into two parts- the metencephalon (after brain) which becomes pons and cerebellum, and the myelencephalon (marrowbrain) which becomes the medulla
  12. Flexures
    Theree flexures/bends occur in the neural tube- the cervical, pontine and the cephalic. The cephalic is most important and is responsible for the horizontal orientation of the brain and the vertical orientation of the spinal cord
  13. Holoprosencephaly
    Prosencephalon fails to divide- lose midline structures of the brain and face--worse case have single eye and nose. Impairments in feeding, cognitive deficits, MR, CP
  14. Agenesis of corpus callosum
    Partially or completeĀ absenceĀ of corpus callosum with impairments in bilateral coordination, motor function, visual perception, MR, CP
  15. Neuroepithelium
    Borders the cavity of the tube, consists of neuronal stem cells that eventually become neuroblasts
  16. Mantle layer
    Surround the neuroepithelium which eventually becomes gray matter of SC
  17. Marginal Layer
    Surrounds the mantle layer and consists of axons. Becomes white matter when they become myelinated

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