USMLE Heme-onc

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Author:
andresjm
ID:
22017
Filename:
USMLE Heme-onc
Updated:
2010-06-04 15:17:30
Tags:
USMLE Step heme onc
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Description:
Heme-onc for Step 1 from FA 2010
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  1. Reed-Sternberg cells surface proteins
    CD30, CD15
  2. t(8;14)
    • c-myc
    • Burkitt's lymphoma
  3. t(11;14)
    • Mantle cell lymphoma
    • CD5+
  4. t(14;18)
    • bcl-2 oncogene expression
    • Follicular lymphoma
  5. Molecular problem for HTLV-1 associated t-cell lymphoma
    TAX inhibits p53
  6. Waldenstrom's macroglobulinemia
    • M spkie and hyperviscosity symptoms
    • No lytic bone lesions
  7. Most common Igs for multiple myeloma
    • IgG
    • IgA
  8. Findings in multiple myeloma
    • Hypercalcemia
    • Renal insufficiency from nephrocalcinosis
    • Anemia
    • Bone/Back pain
  9. t(12;21)
    Means better prognosis in ALL
  10. ALL marker
    TdT+
  11. Smudge cells
    SLL/CLL
  12. TRAP positive
    Hairy cell leukemia
  13. Auer rods
    AML
  14. Responds to all-trans retinoic acid
    AML M3
  15. t(9;22)
    CML, bcr-abl
  16. Auer rods are ____-positive
    Peroxidase
  17. t(11;22)
    Ewing's sarcoma
  18. Birbeck granules
    tennis rackets on EM for langerhans cell histiocytosis
  19. S-100 and CD1a
    Langerhans cell histiocytoses
  20. CD1+
    Langerhans cell histiocytoses
  21. Skin involvement
    Langerhans cell histiocytoses
  22. Disorders with positive JAK2
    • Polycythemia vera
    • Essential thrombocytosis
    • Myelofibrosis

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