An IV admixture is said to be incompatible when the prescribed drugs cannot be combined safely and satisfactorily; may be between tow drugs or between a drug and the solution.
What are the different types of incompatibilities?
Physical, Chemical, and therapeutic
What are physical incompatibilities?
Visual change may be recognized as a change in color, evolution of a gas, development of a haze, or formation of a precipitate, easiest type to detect because it can be seen.
What are chemical incompatibilities?
Occurs when two drugs react to cause the chemical degradation of one or both drugs.
What are the factors affecting incompatibility?
Ph of admixture
Degree of Dilution
Order of Mixing
What is the most common cause of incompatibilities is a combination of two drugs that results in a unstable balance for one of them.
What is buffer capacity?
Ability of a solution to resist a change in pH when either an acidic or basic alkaline substance is added to it.
What is the order of mixing?
By adding the electrolytes such as calcium gluconate, last and mixing well after each addition, the electrolytes are well diluted when they come into contact with each other and the chance of precipitation is minimized.