Biochem Course B

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Author:
patrickedore
ID:
221681
Filename:
Biochem Course B
Updated:
2013-05-30 11:43:47
Tags:
biochemistry
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Description:
course b
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  1. GENE EXPRESSION -PROTEIN REGULATION
    -general transcription factors
    • 1. Remove Histone Proteins
    • 2. Allow RNA Polymerase II to bind
    • 3. Unwind DNA
    • 4. Break ATP for energy
  2. ALLOSTERIC/CO-OPERATIVITY- PROTEIN REGULATION
    -example 1 Fatty acid
    AcetylCoA making Fatty acid/cholesterol

    Enzymes ACC-Carboxylase & HMG CoA.

    Product- inhibitor/ Substrate- Activator
  3. ALLOSTERIC/CO-OPERATIVITY- PROTEIN REGULATION-example 2 Glycolysis
    • Enzyme- PFK1
    • High ATP:Amp = ATP bind allosteric site- shape change- GLYCOLYSIS inhibited

    Low ATP: Amp = Amp bind allosteric site- shape change- GLYCOLYSIS activated
  4. COVALENT MODIFICATION- PROTEIN REGULATION
    (Functional group changes).
    • Mechanism: Amino acid-OH + ATP
    • Shape change- Bulky (-) charge/steric hinderance

    Activation effect: ^Vmax/Low KM

    • Example: Glycogen Phosphorylase activation
    • ACCarboxylase in Liver

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