Drug Adverse Effects & Specific Antidotes

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ssbhat
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221699
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Drug Adverse Effects & Specific Antidotes
Updated:
2013-06-05 18:09:36
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  1. Atropine-like SE
    TCAs
  2. Coronary vasospasm
    Cocaine, sumatriptan, ergot alkyloids
  3. Cutaneous flushing
    • VANC: 
    • Vancomycin
    • Adenosine
    • Niacin
    • Ca2+ channel blockers
  4. Dilated cardiomyopathy
    Doxorubicin (adriamycin), daunorubicin
  5. Torsades de pointes
    Class III (sotalol), class Ia (quinidine) antiarrhythmics
  6. Agranulocytosis
    • Clozapine
    • Carbamazepine
    • Colchicine
    • PTU
    • Methimazole
    • Dapsone
  7. Directed Coombs-positive hemolytic anemia
    Methyldopa
  8. Gray baby syndrome
    Chloramphenicol
  9. Hemolysis in GPD deficient patient
    • (hemolysis IS PAIN)
    • Isoniazid
    • Sulfonamides
    • Primaquine
    • Aspirin
    • Ibuprofin
    • Nitrofurantoin
  10. Megaloblastic anemia
    • (having a blast with PMS)
    • Phenytoin
    • Methotrexate
    • Sulfa drugs
  11. Thrombotic complications
    OCPs
  12. Cough
    ACE inhibitors
  13. Pulmonary fibrosis
    • (it's hard to BLAB when you have pulmonary fibrosis)
    • BLeomycin
    • Amiodarone
    • Busulfan
  14. Acute cholestatic hepatitis
    Macrolides
  15. Focal to massive hepatic necrosis
    • Halothane
    • Valproic Acid
    • Acetaminophen
    • Amanita phalloides
  16. Hepatitis
    INH
  17. Psuedomembranous colitis
    • Clindamycin
    • Ampicilin
  18. Adrenocortical insufficiency
    Glucocorticoid withdrawal (HPA supression)
  19. Gynecomastia
    • (some drugs create awesome knockers)
    • Spironolactone
    • Digitalis
    • Cimetidine
    • Alcohole use
    • Ketoconazole
  20. Hot flashes
    • Tamoxifen
    • Clomiphene
  21. Hypothyroidism
    • Lithium
    • Amiodarone
    • Sulfonamides
  22. Gingival hyperplasia
    • Phenytoin
    • verapamil
  23. Gout
    • Furosemide
    • Thiazides
    • Niacin
    • Cyclosporine
  24. Osteoporosis
    • Corticosteroids
    • Heparin
  25. Photosensitivity
    • (SAT for a photo)
    • Sulfonamides
    • Amiodarone
    • Tetracycline
  26. Stevens-Johnson Syndrome
    • (Everyone Likes Crazy People Always Saying Pretty Please)
    • Ethosuximide
    • Lamotrigine
    • Carbamazepine
    • Phenobarbital
    • Allopurinol
    • Sulfa drugs
    • Phenytoin
    • PCN
  27. Tendonitis, tendon rupture, and cartilage damage (kids)
    Fluoroquinolones
  28. Fat redistribution
    • Glucocorticoids
    • Protease inhibitors
  29. Myopathies
    • (Five Nice Prompt Girl Children Had Intercourse Saturday)
    • Fibrates
    • Niacin
    • Penacillamine
    • Glucocorticoids
    • Colchicine
    • Hydroxychloroquine
    • Interferona-alpha
    • Statins
  30. Fanconi Syndromw
    Expired tetracycline
  31. Interstitial nephritis
    Methicillin, NSAIDs, furosemide
  32. Hemorrhagic cystitis
    Cyclophosphamide, ifosfamide (prevent via mesna)
  33. SIADH
    carbamazepine, cyclophosphamide
  34. Cinchonisim
    Quinidine, quinine
  35. Diabetes insipidus
    Lithium, demeclocycline
  36. Parkinson-like syndrome
    • (Hail Mary Christ Resurrected)
    • Haloperidol
    • Metoclopramide
    • Chlorpromazine
    • Reserpine
  37. Seizures
    Bupropion, imipenem/cilastatin, isoniazid, tramadol, enflurane, metoclopramide
  38. Tardive dyskinesia
    Antipsychotics
  39. Disulfiram-like Rxn
    Metronidazole, certain cephalosporins, procarbazine, 1st gen sulfonylureas
  40. Nephrotoxicity/neurotoxicity
    Polymyxins
  41. Nephrotoxicity, ototoxicity
    Aminoglycosides, vancomycin, loop diuretics, cisplatin
  42. Antimuscarinic
    Atropine, TCAs, H1-blockers, neuroleptics
  43. Acetaminophen
    N-acetylcystein (also used for CF)
  44. Salicylates
    NaHCO3(alkilinize urine), dialysis
  45. Amphetamines 
    NH4Cl(acidify urine)
  46. Acetylcholinesterase inhibitors, organophosphates
    Atropine, pralidoxime
  47. Antimuscarinic, anticholinergic agents
    Physostigmine salicylate
  48. Beta-blockers
    Glucagon
  49. Digitalis
    Stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
  50. Iron, aluminum
    Deferoxamine
  51. Lead
    CaEDTA, dimercaprol, succimer, penicillamine
  52. Mercury, arsenic, cold
    Dimercaprol (BAL), succimer
  53. Copper, arsenic, gold
    Penicillamine
  54. Cyanide
    Nitrite, hydroxocobalamin, thiosulfate
  55. Methemoglobin
    Methylene blue, vitamin C
  56. Carbon dioxide
    100% O2, hyperbaric O2
  57. Methanol, ethylene glycol (antifreeze)
    Ethanol, dialysis, fomepizole(competitive inhibitor of alcohol dehydrogenase)
  58. Opioids
    Naloxone, naltrexone
  59. Benzodiazepines
    Flumazenil
  60. TCAs
    NAHCO3 (plasma alkalinization)
  61. Heparin
    Protamine
  62. Warfarin
    Vitamin K, french frozen plasma
  63. tPA, streptokinase
    Aminocaproic acid
  64. Theophylline
    beta-blocker
  65. Night blindness, dry skin
    Vitamin A deficiency
  66. Arthralgias, fatigue, headaches, skin changes, sore throat, alopecia
    Vitamin A excess
  67. Wernicke-Korsakoff Syndrome
    • Vitamin B1 deficiency (thiamine)
    • Dry beriberi- polyneuritis, symmetrical muscle wasting
    • Wet beriberi- high-output cardiac failure, edema
  68. Cheliosis (inflammation of lips, scaling and fissures at the corners of the mouth), corneal vascularization
    Vitamin B2 (riboflavin) deficiency
  69. Glossitis, Hartnup disease, pellagra, malignant carcinoid syndrome
    Vitamin B3 (niacin) deficiency
  70. Derived from tryptophan, requires vitamin B6 for synthesis
    Vitamin B3 (niacin)
  71. Facial flushing (d/t pharmacologic doses for treatment of hyperlipidemia)
    Vitamin B3 (niacin) excess
  72. Dermatitis, enteritis, alopecia, adrenal insufficiency
    Vitamin B5 (pantothenate) deficiency
  73. Convulsions, hyperirritabilit, peripheral neuropathy, sideroblastic anemias
    Vitamin B6 (pyridoxine) defiency

    deficiency inducible by isoniazid
  74. Increased fragility of erythrocytes (hemolytic anemia), muscle weakness, poster column and spinocerebellar tract demyelination (closely mimics Friedrich ataxia)
    Vitamin E deficiency
  75. Delayed wound healing, hypogonadism, decreased adult hair, dysguesia, anosmia, may predispose to alcoholic cirrhosis
    Zinc deficiency
  76. Severe fasting hypoglycemia, increase glycogen in liver, increase blood lactate, HSM, seizures
    Von Gierke's disease- glucose-6-phosphate
  77. Cardiomegaly and systemic findings leading to early death
    Pompe's disease - lysosomal alpha1,4 glucosidase (acid maltase)
  78. Milder form of Von Gierke's w/ normal blood lactate levels
    Cori's disease - Debranching enzyme (alpha1,6 glucosidase)
  79. Increased glycogen in muscle that cannot be broken down leading to painful muscle cramps, myoglobinuria w/ strenous exercise
    McArdle's disease - glycogen phosphorlyase
  80. Peripheral neuropathy of hands/feet, angiokeratomas, CV/renal disease
    Fabrys disease - alpha-galactosidase A --> ceramide trihexoside
  81. HSM, aseptic necrosis of femur, bone crises,  macrophages that look like crumpled tissue paper
    Gauchers - beta-glucocerebrosidase
  82. progressive neurodegeneration, HSM, cherry-red spot on macla, foam cells
    Niemann-Pick disease - sphingomyelinase
  83. Progressive neurodegeneration, developmental delay, cherry red spot on macula, lysosomes with onion skin, no HSM
    Tay-Sachs - Hexominidase A --> GM2 ganglioside
  84. Peripheral neuropathy, developmental delay, optic atrophy, globoid cells
    Krabbe's disease - Galactocerebrosidase
  85. Central and peripheral demyelination with ataxia, dementia
    Metachromatic leukodystrophy - arylsulfatase A - cerebroside sulfate
  86. developmental delay, gargoylism, airway obstruction, corneal clouding, HSM
    Hurler's syndrome - alpha-L-iduronidase - heparan sulfate, dermatan sulfate
  87. aggressive behavior, no corneal clouding
    Hunter's syndrome (milder Hurler's) - Iduronate sulfatase - heparan sulfate, dermatan sulfate
  88. Failure to thrive, steatorrhea, acanthocytosis, ataxia, night blindess
    Abeta-lipoproteinemia
  89. 1st arch neural crest fails to migrate - mandibular hypoplasia, facial abnormalities
    Treacher Collin's Syndrome

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