Nicotinic Ach receptor is one of the best characterized of all the cell surface receptors. Explain how it works
When Ach, binds to the alpha subunits on that receptor, that causes internal aqueous channel or pore to open transiently, and when that happens Na will go in from ECF into cell. It’s a rapid signaling mechanism. GABA also acts through this mechanism. Since we’re talking about Ach receptor, the function of many of these agents is to act as an agonist, Succinylcholine. The antagonist at the nicotinic Ach receptor is the non-depolarizing muscle relaxants.