Hematology Chapter 16: Exam IV

A malignant disease of hematopoietic tissue, characterized by replacement of normal bone marrow elements with abnormal (neoplastic) blood cells:

A rapidly progressive disease characterized by an abnormal expansion of immature cells or blasts:

A slowly progressive disorder characterized by an abnormal expansion of mature cells:

Leukemia can be divided into two major cell types:

What are the most common types of leukemia that occur in older adults?

What is the most common form of leukemia in children?

What leukemia, whether lymphoid or myeloid lineage, is generally considered to be a disease of adults?

Chronic or Acute Leukemia—All ages, clinical onset is sudden, immature leukemic cells, anemia, thrombocytopenia, variable WBC count, mild organomegaly:

Chronic or Acute Leukemia—Adults, clinical onset is insidious, mature leukemic cells, mild anemia, mild thrombocytopenia, increased WBC count, prominent organomegaly:

Abrupt onset of signs and symptoms of only a few weeks, weakness, bleeding abnormalities, flu-like symptoms all reflect the failure of bone marrow to produce adequate normal cells; caused by the proliferation and accumulation of leukemic cells in the marrow:

A myeloid or granulocytic sarcoma is defined as a tumor mass of myeloid cells outside of the marrow and may be the first evidence of:

Gingival hypertrophy and oral lesions are primarily seen in:

A mediastinal mass resulting from thymic involvement is a hallmark of:

Bone or joint pain, caused by pressure of expanding leukemic call population in the marrow cavity, commonly accompanies:

When are Myelodysplastic Syndromes more common?

What are the major characteristics of AML?

What are the major characteristics of ALL and ALL?