Anaplasia

Card Set Information

Author:
priragaa
ID:
222164
Filename:
Anaplasia
Updated:
2013-06-03 04:56:56
Tags:
Anaplasia Neoplasia
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Description:
Features of Anaplasia and Differentiation
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  1. Nuclear morphology of cancer cells?
    Hyperchromatia
  2. Normal Nuclear to Cytoplasm Ratio
    1:4 or 1:6
  3. Nuclear to Cytoplasm Ratio in Cancer Cells
    1:1
  4. Morphology of Mitosis is Cancer Cells
    Atypical, Bizzare with multipolar spindles
  5. Dysplasia
    Loss of uniformity of individual cells as well as their structural organisation.
  6. Smallest detectable clinical mass of tumor?
    1g or 10^9 cells
  7. Number of doublings to produce a clinically detectable mass?
    30
  8. Additional doubling to produce 1kg mass?
    10
  9. No. of cells in 1kg mass?
    10^12
  10. Factors determining rate of growth of tumor?
    • 1. Doubling time of cells
    • 2.Fraction of tumor in replicative pool 
    • 3. Rate at which cells shed or die
  11. Growth fraction and chemotherapy
    Higher the growth fraction more response to chemotherapy cause the drugs act on cells that are in cell cycle.

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