What is antibody –dependent cell mediated
cytotoxicity and what does it kill?
This function resembles opsonization in that the target organism becomes coated with antibodies. However, the destruction of the target cell is by immune system cells that remain external to the target cell. If an organism, such as a parasitic worm, is too large for ingestion and destruction by phagocytosis, it can be attacked by immune system cells that remain external to it. The garget cell is first coated with antibodies. The cells of the immune system, such as eosinophils, macrophages, and NK cells, bind to the Fc regions of the attached antibodies. Finally, the target cell is then lysed by substances secreted by the cells of the immune system.