Pharm Chapter 18

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Pharm Chapter 18
2013-06-04 00:04:13

Pharm Chapter 18
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  1. ________ is a beta1-selective vasoactive adrenergic drug that is structurally similar to the naturally occurring catecholamine _______. Trhroug stimulation of the beta 1 receptors on heart muscle, it increases cardiac output by increasing contractility, which increases the stroke volume especially in patients with heart failure.
    Dobutamine (Dobutrex)
  2. ______ is a naturally occurring catecholamine neurotransmitter in the SNS. It has potent dopaminergic as well as beta 1 and alpha 1 adrenergic receptor activity. At low dosage it can dilate blood vessels in the brain, heart, kidneys, and mesentery, which increase blood flow to these areas. At high dosage (infusion) it can improve cardiac contractility and output
    Dopamine (Intropin)
  3. _______ is an endogenous vasoactive catecholamine. It acts directly on both the alpha and beta adrenergic receptors of tissues inervated by the SNS. It is administered in emergency situations and is one of the primary vasoactive drugs used in many advanced cardiac life support protocols.
    Epinephrine (Adrenalin)
  4. _____ The physiologic response by this drug is dose related. At low doses it stimulates mostly beta 1 adrenergic receptors, increasing the force of contraction and heart rate. It is also used to treat acute asthma and anaphylactic shock at these dosages because it has significant bronchodilatory effects via the beta 2 adrenergic receptors in the lungs.
    Epinephrine (Adrenalin)
  5. ________ At high dosages this drug stimulates mostly alpha adrenergic receptors, causing vasoconstriction, which elevates blood pressure
    Epinephrine (Adrenalin)
  6. ______ is a peripheral dopamine 1 (D1) agonist indicated for parenteral use in lowering blood pressure
    Fenoldopam (Corlopam)
  7. _____ is a prodrug converted to its active form, desglymidodrine. It is this active metabolite that is responsible for the primary pharmacologic action of ______, which is alpha 1 adrenergic receptor stimulation. This alpha 1 stimulation causes constriction of both arterioles and veins, resulting in peripheral vasoconstriction. ______ IS PRIMARILY INDICATED FOR THE TREATMENT OF SYMPTOMATIC ORTHOSTATIC HYPOTENSION.
    Midodrine (ProAmatine)
  8. _____ acts prdominantly by directly simulating alpha adrenergic receptors, which leads to vasoconstriction. It also has some direct stimulating beta adrenergic effects on the heart (beta 1) but none on the lung (beta2). _______ is directly metabolized to dopamine and is used primarily in the treatment of hypotension and shock.
    Norepinephrine (Levophed)
  9. _______ works almost exclusively on the alpha adrenergic receptors. It is used primarily for short term treatment to raise blood pressure in patients in shock, to control some dysrhythmias (supraventricular tachycardias) and to promote vasoconstriction in regional anesthesia. 
    phenylephrine (Neo-Synephrine)