PHM 111 Week 1
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Explain the clotting process.
Injured tissues release thromboplastin, a substance that triggers the clotting mechanism.
What is the MOA of anticoagulants?
- Inhibition of performed clotting factors (Heparin)
- Prevention of synthesis of normal clotting factors( Coumadin derivatives)
- Therapy is focused on preventing intravascular thrombosis by decreasing blood coagulability
- Prevention of venous thrombosis
- colt suppression prior to blood transfusions
Adverse reactions of anticoagulants?
Major ADR for both types of drugs are hemorrhage
What must be monitored when using anticoagulants?
- Partial Thromboplastin Time (PPT)
- Measures the function of the intrinsic and common pathways that are affected by heparin.
Name the 3 specific anticoagulants?
- Low Molecular Weight Heparins
- Inhibits thrombin activity so that fibrin cannot be formed
- Derived from pork and beef lungs and intestinal tissue
- Dose titrated according to PTT
- Antidote is protamine sulfate
Explain Low Molecular Weight Heparings
- Are smaller and have lower molecular weight than heparin
- Same mechanism of action as heparin
- Longer half-life than heparin
- Given SC
- Less lab monitoring required
- Fragmin & Lovenox CAN NOT be used interchangeably (unit for unit) with each other or with heparin.
- Does not affect established clots, but does prevent further extension of formed clots
- Indicated for prophylaxis and treatment of deep vein thrombosis and pulmonary thromboembolism
- Also used for prophylaxis of thromboembolism associated with a trial fibrillation or myocardial infraction
- Dose id titrated based on target INR (International Normalized Ration)
What are the side effects of warfarin?
Crosses placenta and causes hemorrhage in fetus.
What is the antidote of warfarin?
What would you like to do?
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