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S Aureus and S Pyogenes
ADP ribosylating A-B Toxins?
- Corynebacterium Diphtheriae, vibrio cholerae
- E. Coli, Bordetella Pertussis
- Clostridium Perfringes
- C. Tetani
- C. botulinum
- Bacillus anthracis
- S. pyogenes
- Super Antigen
- TSST-1 superantigen causes toxic shock syndrome,
- food poisoning as well as exfoliatin which causes scalded skin syndrome
Scarlet fever-erthrogenic toxin causes toxic shock-like syndrome
Inactivates EF-2; causes pharyngitis and "pseudomembrane" in throat
ADP ribosylation of G protein stimulates adenylyl cyclase. Increases pumping of Cl- into gut and decreases Na absorbtion. H2O moves into lumen causing rice-water diarrhea.
Heat-labile toxin Adenylate cyclase. Heat-stable stimulates Guanylate cyclase. Both cause watery diarrhea. Labile like Air, Stable like Ground
Inc. cAMP by (-) G-alpha1. causes whooping cough, (-) chemokine receptor, causes lymphocytosis
alpha toxin, a lecithinase that acts as a phospholipase to cleave cell membranesand causes gas gangrene; get a dbl zone of hemolysis on blood agar.
blocks release of inhibitory neurotransmitters GABA and glycine. causes lockjaw.
blocks realease of ACh, causes anticholinergic symptoms, CNS paralysis. spores found in canned food and honey (floppy baby)
Edema factor, part of toxin complex, IS AN adenylate cyclase.
shiga toxin cleaves host cell rRNA (inactivates 60s). also enhances cytokine release, causing HUS.
Streptolysin O is a hemolysin. antigen for ASO antibody, which is used in the diagnosis of rheumatic fever.