Immunology Misc.

Card Set Information

Immunology Misc.
2013-06-22 19:07:12
USMLE First Aid

Misc stuff need to remember from immunology
Show Answers:

  1. Drains to which lymph node?

    Upper limb, lateral breast
  2. Drains to which lymph node?

  3. Drains to which lymph node?

    Duodenum, jejunum
    Superior mesenteric
  4. Drains to which lymph node?

    Sigmoid colon
    Colic --> inferior mesenteric
  5. Drains to which lymph node?

    Rectum (lower portion) of anal canal (above pectinate line)
    Internal iliac
  6. Drains to which lymph node?

    Anal canal (below pectinate line)
    Superficial inguinal
  7. Drains to which lymph node?

    Superficial and deep plexuses --> para-aortic
  8. Drains to which lymph node?

    Superficial inguinal
  9. Drains to which lymph node?

    Thigh (superficial)
    Superficial inguinal
  10. Drains to which lymph node?

    Lateral side of dorsum of foot
  11. Right lymphatic duct receives drainage from..
    Right arm and right half of head
  12. Thoracic duct receives drainage from...
    everywhere else (besides right arm and right half of head)
  13. Howell-Jolly bodies in RBCs

    (small fragment of DNA that didn't get extruded as it should have. stains dark blue spot (basophilic))
    seen in postsplenectomy (b/c spleen normally clears these cells)

    along with target cells and thrombocytosis
  14. HLA-A3

    (MHC I)
  15. HLA-B27

    (MHC I)

    Psoriasis, Ankylosing spondylitis, Inflammatory bowel disease (IBD), Reactive arthritis (Reiter's syndrome)
  16. HLA-B8

    (MHC I)
    Graves' disease
  17. HLA-DR2

    (MHC II)
    Multiple sclerosis, hay fever, SLE, Goodpasture's
  18. HLA-DR3

    (MHC II)
    DM type 1
  19. HLA-DR4

    (MHC II)
    Rheumatoid arthritis, DM type 1
  20. HLA-DR5

    (MHC II)
    Pernicious anemia --> B12 deficiency, Hashimoto's thyroiditis
  21. HLA-DR7

    (MHC II)
    Steroid-responsiveness nephrotic syndrome
  22. Hot T-Bone stEAk
    • IL-1: fever (hot)
    • IL-2: stimulates T cells
    • IL-3: stimulates Bone marrow
    • IL-4: stimulates IgE (and IgG) production. also differentiation into Th2
    • IL-5: stimulates IgA production. differentiation of B cells to class switch to IgA. simulates growth of eosinophils

    • Secreted by...
    • IL-1 (macrophage)
    • IL-2 (T cell)
    • IL-3 (T cell)
    • IL-4 (Th2 cell)
    • IL-5 (Th2 cell)
  23. IL-6
    • An endogenous pyrogen - causes fever
    • Stimulates production of acute-phase proteins

    Secreted by macrophages (and CD4+ T helper cells too!)
  24. IL-8
    "Clear up on aisle 8!"

    Recruits neutrophils to clear infections (i.e. chemotactic factor for neutrophils)

    Secreted by macrophages
  25. IL-12
    • Differentiation of T cell into Th1 cell
    • Activates NK cells

    Secreted by macrophages (and B cells too!)
  26. TNF-α
    • Mediates septic shock
    • Causes leukocyte recruitment and vascular leak

    Secreted by macrophages
  27. Interferon-γ (IFN-γ)
    • Activates macrophages and Th1 cells
    • Suppresses Th2
    • ↑ MHC I and MHC II expression to mediate killing of virally-infected cell

    Secreted by Th1 cells
  28. IL-10
    • Keeps check on inflammatory response (inhibits T cells and Th1)
    • Activates Th2

    Secreted by Th2 (and Regulatory T cells too)
  29. TNF-β
    like IL-10, inhibits inflammation
  30. Interferon-α & -β
    inhibits viral protein synthesis (ribonucleases degrade viral mRNA)

    activates NK cells to kill virally-infected cells

    Interferes with viruses
  31. T cell surface proteins
    TCR, CD3 (assoc. w/ TCR), CD28 (binds B7 on APC)

    Helper T cell: CD4, CD40L (binds CD40 in B cell)

    Cytotoxic T cell: CD8
  32. B cell surface proteins
    Ig, CD19, CD20, CD21 (binds EBV), CD40 (binds CD40L on APC?), MHC II, B7 (binds CD28 on APC)
  33. Macrophage surface cell markers
    MHC II, B7 (binds to CD28 on T cell), CD40 (binds to CD40L on B cell), CD14, receptor for Fc and C3b (opsonization)
  34. NK cell surface proteins
    receptors for MHC II, B7 (binds to CD28 on T cell), CD16 (binds Fc of IgG), CD56 (unique marker for NK cell)
  35. All cells express MHC I except...
    mature RBCs
  36. Antinuclear antibodies (ANA)

    SLE, nonspecific
  37. Anti-dsDNA, anti-Smith


    Anti-dsDNA - poor prognosis
  38. Antihistone

    Drug-induced lupus
  39. Rheumatoid factor (anti-Fc of IgG), Anti-CCP

    Rheumatoid arthritis
  40. Anticentromere

    Scleroderma (CREST syndrome)
  41. Anti-Scl-70 (anti-DNA topoisomerase I)

    Scleroderma (diffuse)
  42. Antimitochondrial

    1° biliary cirrhosis
  43. IgA antiendomysial, IgA anti-tissue transglutaminase

    * endomysium surrounds individual muscle fibers

    Celiac disease
  44. Anti-basement membrane

    Goodpasture's syndrome
  45. Anti-desmoglein

    Pemphigus vulgaris - chronic blistering skin disease (loss of cohesion between keratinocytes)
  46. Antimicrosomial, antithyroglobulin

    Hashimoto's thyroiditis
  47. Anti-Jo-1, anti-SRP, anti-Mi-2

    Polymyositis, dermatomyositis - chronic inflammation of muscles
  48. Anti-SS-A (anti-Ro)

    Sjögren's syndrome - lymphocyte infiltration of exocrine glands (dry mouth, dry eyes, dry skin)

    * lecturer says anti-Ro is for neonatal lupus
  49. Anti-SS-B (anti-La)

    Sjögren's syndrome - lymphocyte infiltration of exocrine glands (dry mouth, dry eyes, dry skin)

    *lecturer says anti-La is for neonatal lupus
  50. Anti-U1 RNP (ribonucleoprotein)

    Mixed connective tissue disease
  51. Anti-smooth muscle

    Autoimmune hepatitis
  52. Anti-glutamate decarboxylase

    DM Type 1

    ( Glutamate ---glutamate decarboxylase---> GABA)
  53. c-ANCA (PR3-ANCA)

    Wegener's granulomatosis, i.e. granulomatosis with polyangiitis
  54. p-ANCA (MPO-ANCA)

    Microscopic polyangiitis, Churg-Strauss syndrome
  55. Aldesleukin (interleukin-2)

    <recombinant cytokine>
    used for...

    Renal cell carcinoma, metastatic melanoma
  56. Erythropoietin (epoetin)

    <recombinant cytokine>
    used for...

    Anemias (esp. in renal failure)
  57. Filgrastatin (granulocyte colony-stimulating factor)

    <recombinant cytokine>
    used for...

    Recovery of bone marrow
  58. Sargramostim (granulocyte-macrophage colony-stimulating factor)

    <recombinant cytokine>
    used for...

    Recovery of bone marrow
  59. α-interferon

    <recombinant cytokine>
    use for...

    Hepatitis B and C, Kaposi's sarcoma, leukemias, malignant melanoma
  60. β-interferon

    <recombinant cytokine>
    used for...

    Multiple sclerosis
  61. γ-interferon

    <recombinant cytokine>
    used for...

    Chronic granulomatous disease
  62. Oprelvekin (interleukin-11)

    <recombinant cytokine>
    used for...

  63. Thrombopoietin

    <recombinant cytokine>
    use for...

  64. Muromonab-CD3 (OKT3)
    target - CD3

    use - prevent acute transplant rejection
  65. Digoxin Immune Fab
    target - digoxin

    use - antidote for digoxin intoxication
  66. Infliximab
    target - TNF-α

    use - Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (CRAP)
  67. Adalimumab
    target - TNF-α

    use - Crohn's disease, rheumatoid arthritis, psoriatic arthritis
  68. Abciximab
    target - Glycoprotein IIb/IIIa

    use - prevent cardiac ischemia in unstable angina and in pts treated with percutaneous coronary intervention
  69. Trastuzumab (Herceptin)
    target - HER2

    use - HER-2 overexpressing breast cancer
  70. Rituximab
    target - CD20

    use - B-cell non-Hodgkin's lymphoma
  71. Omalizumab
    target - IgE

    use - Additional line of treatment for severe asthma