Disease 23 - PCO

Card Set Information

Author:
sookylala
ID:
224849
Filename:
Disease 23 - PCO
Updated:
2013-06-24 09:05:19
Tags:
PCO
Folders:

Description:
PCO
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  1. risk factors of cataracts
    • female
    • history
    • uv
    • smoking
    • trauma
    • diabetes
    • aging
  2. nuclear?
    • MOST COMMON!
    • changes in structural proteins
    • yellowing and hardening
  3. cortical cataract
  4. anterior subcapsular cataract?
    • dense light scattering fibrotic regions under anterior capsule
    • focal star shaped opacity
  5. TGFb
    potent inducer of fibrosis
  6. phacoemulsification
    titanium vibrating high speed-> ultrasonic waves break up nucleus of lens into smaller pieces-> fragments aspired through a hollow needle
  7. PCO?
    • major comp of cataract surgery
    • proliferation and migration of residualr lens epi cells
    • fibrosis
  8. FGF
    • exposure of lens epithelial to FGF-> lens cell growth, proliferate and migrate and differentiate
    • FGFR1 inhibition-> retards lens cell growth onto the posterior capsule
  9. IOL?
    square edge create a barrier that will retard cell growth in post capsule

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