-
t(9;22)
- CML
- Philadelphia chromosome
- bcr-abl - bcr (22), abl (9)(tyrosine kinase)
-
CML
- Philadelphia chromosome
- t(9;22)
- bcr-abl - bcr (22), abl (9)(tyrosine kinase)
-
t(8;14)
- Burkitt's lymphoma
- c-myc (8)(growth promotion)
-
Burkitt's lymphoma
- t(8;14)
- c-myc (8)(growth promotion)
-
t(14;18)
- Follicular lymphoma
- bcl-2 (18)(anti-apoptosis)
- Ig heavy chain (14)
-
Follicular lymphoma
- t(14;18)
- bcl-2 (18)(anti-apoptosis)
- Ig heavy chain (14)
-
t(15;17)
- M3 type of AML (i.e. APL)
- PML protein (15)(tumor suppressor)
- RAR-α (17)
- Tx: all-trans retinoic acid to mature the blasts
-
APL (M3 type of AML)
- t(15;17)
- PML protein (15)(tumor suppressor)
- RAR-α (17)
- Tx: all-trans retinoic acid to mature the blasts
-
t(11;22)
Ewing's sarcoma - bone tumor
-
-
t(11;14)
- Mantle cell lymphoma
- cyclin D1 (11)(G1-->S)
- Ig heavy chain (14)
-
Mantle cell lymphoma
- t(11;14)
- cyclin D1 (11)(G1-->S)
- Ig heavy chain (14)
-
t(12;21)
ALL w/ better prognosis
-
ALL w/ better prognosis
t(12;21)
-
Robertsonian translocation
- Nonreciprocal chromosome translocation involving a pair of one of these:
- 13,14,15,21,22
- ^ these are acrocentric, i.e. centromere is near one end
- A pair of these different chromosomes fuse at the centromere and the short arms are lost
- Balanced (ok), Unbalanced (Down (21), Patau's (13), abortion)
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