Chromosomal translocations

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Author:
certainlygirl
ID:
225173
Filename:
Chromosomal translocations
Updated:
2013-06-27 02:58:27
Tags:
USMLE chromosomal translocations First aid
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chromosome translocations to know
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  1. t(9;22)
    • CML
    • Philadelphia chromosome
    • bcr-abl - bcr (22), abl (9)(tyrosine kinase)
  2. CML
    • Philadelphia chromosome
    • t(9;22)
    • bcr-abl - bcr (22), abl (9)(tyrosine kinase)
  3. t(8;14)
    • Burkitt's lymphoma
    • c-myc (8)(growth promotion)
  4. Burkitt's lymphoma
    • t(8;14)
    • c-myc (8)(growth promotion)
  5. t(14;18)
    • Follicular lymphoma
    • bcl-2 (18)(anti-apoptosis)
    • Ig heavy chain (14)
  6. Follicular lymphoma
    • t(14;18)
    • bcl-2 (18)(anti-apoptosis)
    • Ig heavy chain (14)
  7. t(15;17)
    • M3 type of AML (i.e. APL)
    • PML protein (15)(tumor suppressor)
    • RAR-α (17)
    • Tx: all-trans retinoic acid to mature the blasts
  8. APL (M3 type of AML)
    • t(15;17)
    • PML protein (15)(tumor suppressor)
    • RAR-α (17)
    • Tx: all-trans retinoic acid to mature the blasts
  9. t(11;22)
    Ewing's sarcoma - bone tumor
  10. Ewing's sarcoma
    • t(11;22)
    • bone tumor
  11. t(11;14)
    • Mantle cell lymphoma
    • cyclin D1 (11)(G1-->S)
    • Ig heavy chain (14)
  12. Mantle cell lymphoma
    • t(11;14)
    • cyclin D1 (11)(G1-->S)
    • Ig heavy chain (14)
  13. t(12;21)
    ALL w/ better prognosis
  14. ALL w/ better prognosis
    t(12;21)
  15. Robertsonian translocation
    • Nonreciprocal chromosome translocation involving a pair of one of these:
    • 13,14,15,21,22
    • ^ these are acrocentric, i.e. centromere is near one end
    • A pair of these different chromosomes fuse at the centromere and the short arms are lost
    • Balanced (ok), Unbalanced (Down (21), Patau's (13), abortion)

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