FU I'll bust you a CAP in your Pancreas, Breast, Colon. Take (that) Sucker
inhibits synthesis of pyrimidine (C, T, U)
inhibits Thymidate synthase thus decreased dTMP, decreased DNA and protein synthesis
When used with Leucovarin, it acts as an amplifying agent
Used for metastatic breast cancer,carcinoma of GI, ovary,bladder, pancreas, prostate. Also metastatic cancer of the colon
AE is nausea and alopecia. Also diarrhea. Also myelosuppression.