Endocrine

Card Set Information

Author:
certainlygirl
ID:
225300
Filename:
Endocrine
Updated:
2013-06-28 17:10:43
Tags:
signaling molecules pathway USMLE First Aid
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Description:
Signaling pathways of endocrine hormone
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  1. cAMP
    • FSH, LH
    • CRH, ACTH, MSH
    • TSH, PTH, calcitonin
    • ADH (V2 receptor)
    • hCG
    • GHRH
    • glucagon

    FLAT CHAMP
  2. cGMP
    ANP, NO (a type of "edothelium-derived relaxing factor" (EDRF))

    - ANP released in response to high blood pressure. Exact opposite effect of aldosterone

    Think vasodilators
  3. IP3
    • GnRH, Oxytocin
    • TRH
    • angiotensin II, ADH (V1 receptor)
    • histamine (H1), gastrin
    • GHRH (minor role)
  4. Steroid receptor
    Cytosolic:

    • Vitamin D
    • Estrogen, Progesterone, Testosterone
    • Cortisol
    • Aldosterone

    Nuclear:

    T3/T4
  5. Intrinsic tyrosine kinase
    (MAP kinase pathway)
    • Insulin
    • IGF-1, FGF, PDGF, EGF

    • Think growth factors
    • "MAP out the growth"
  6. Receptor-associated tyrosine kinase
    (JAK/STAT pathway)
    • GH, prolactin (acidophiles)
    • Immunomodulators (e.g. cytokines IL-2, IL-6, IL-8, IFN)
  7. Somatotrope

    anterior pituitary cell that releases...
    GH
  8. Thyrotrope

    anterior pituitary cell that releases...
    TSH
  9. Lactotrope

    anterior pituitary cell that releases...
    PRL
  10. Gonadotropes

    anterior pituitary cell that releases...
    FSH, LH
  11. Corticotropes

    anterior pituitary cell that releases...
    ACTH
  12. Acidophile hormones
    • Somatotropes - GH
    • Lactotropes - PRL
  13. Basophile hormones
    • Thyrotropes - TSH
    • Gonadotropes - FSH, LH
    • Corticotropes - ACTH, MSH

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