Blood Bank MLS Review

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Author:
mbailey585
ID:
225920
Filename:
Blood Bank MLS Review
Updated:
2013-07-06 00:37:33
Tags:
Blood Bank MLS Review Genetics Immunology Groups ABO Group System
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Description:
Blood Bank MLS Review, 1-18 Genetics and Immunology of Blood Groups, 19-36 ABO Blood Group System
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  1. What type of serological testing does the blood bank technologist perform when determining the blood group of a patient?

    A. genotyping
    B. both genotyping and phenotyping
    C. polymerase chain reaction
    D. phenotyping
    D. phenotyping
    (this multiple choice question has been scrambled)
  2. If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the antibody is demonstrating:

    A. dosage
    B. linkage disequilibrium
    C. homozygosity
    D. heterozygosity
    A. dosage
    (this multiple choice question has been scrambled)
  3. Carla expresses the blood group antigens Fya, Fyb, and Xga. James shows expressions of none of these antigens. What factor(s) may account for the absence of these antigens in James?

    A. medication
    B. gender and race
    C. gender
    D. race
    B. gender and race
    (this multiple choice question has been scrambled)
  4. Which of the following statements is true?

    A. an individual with the BO genotype is homozygous for B antigen
    B. an individual with the BB genotype is homozygous for B antigen
    C. an individual with the OO genotype is heterozygous for O antigen
    D. an individual with the AB phenotype is homozygous for A and B antigens
    B. an individual with the BB genotype is homozygous for B antigen
    (this multiple choice question has been scrambled)
  5. Which genotype is heterozygous for C?

    A. Dce/dce
    B. DCe/dce
    C. DCE/DCE
    D. DCE/dCe
    B. DCe/dce
    (this multiple choice question has been scrambled)
  6. Which genotype(s) will give rise to the Bombay phenotype?

    A. HH and Hh
    B. hh only
    C. HH only
    D. Hh and hh
    B. hh only
    (this multiple choice question has been scrambled)
  7. Meiosis in cell division is limited to the ova and sperm producing four gametes containing what complement of DNA?

    A. 3N
    B. 1N
    C. 2N
    D. 4N
    B. 1N
    (this multiple choice question has been scrambled)
  8. A cell that is not actively dividing is said to be in:

    A. telophase
    B. anaphase
    C. interphase
    D. prophase
    C. interphase
    (this multiple choice question has been scrambled)
  9. Which of the following describes the expression of most blood group antigens?

    A. recessive
    B. dominant
    C. corecessive
    D. codominant
    D. codominant
    (this multiple choice question has been scrambled)
  10. What blood type is not possible for an offspring of an AO and BO mating?

    A. AB
    B. O
    C. A or B
    D. all are possible
    D. all are possible
    (this multiple choice question has been scrambled)
  11. The alleged father of a child in a disputed case of paternity is blood group AB. The mother is group O and the child is group O. What type of exclusion is this?

    A. indirect/secondary/second/second order
    B. probability
    C. direct/primary/first order
    D. random
    A. indirect/secondary/second/second order
    (this multiple choice question has been scrambled)
  12. If the frequency of gene Y is 0.4 and the frequency of gene Z is 0.5, one would expect that they should occur together 0.2 (20%) of the time. In actuality, they are found together 32% of the time. This is an example of:

    A. linkage disequilibrium
    B. crossing ovcer
    C. polymorphism
    D. chimerism
    A. linkage disequilibrium
    (this multiple choice question has been scrambled)
  13. IN the Hardy-Weinberg formula, p2 represents:

    A. the heterozygous population of one allele
    B. the recessive allele
    C. the homozygous population of one allele
    D. the dominant allele
    C. the homozygous population of one allele
    (this multiple choice question has been scrambled)
  14. In this type of inheritance, the father carries the trait on his X chromosome. He has no sons with the trait because he passed his Y chromosome to his sons; however, all his daughters will express the trait.

    A. X-linked recessive
    B. X-linked dominant
    C. autosomal dominant
    D. autosomal recessive
    B. X-linked dominant
    (this multiple choice question has been scrambled)
  15. Why do IgM antibodies, such as those formed against the ABO antigens, have the ability to directly agglutinate red blood cells (RBCs) and cause visible agglutination?

    A. IgM antibodies are not limited by subclass specificity
    B. IgM antibodies tend to clump together more readily to bind more antigen
    C. IgM antibodies are found in greater concentrations than IgG antibodies
    D. IgM antibodies are larger molecules and have the ability to bind more antigen
    D. IgM antibodies are larger molecules and have the ability to bind more antigen
    (this multiple choice question has been scrambled)
  16. Which of the following enhancement mediums decreases zeta potential, allowing antibody and antigen to come closer together?

    A. ZZAP
    B. polyethylene glycol
    C. polybrene
    D. LISS
    D. LISS
    (this multiple choice question has been scrambled)
  17. This type of antibody response is analagous to an anamnestic antibody reaction.

    A. tertiary
    B. anaphylactic
    C. primary
    D. secondary
    D. secondary
    (this multiple choice question has been scrambled)
  18. Which antibodies to a component of complement are contained in the rabbit polyspecific antihuman globulin reagent for detection of in vivo sensitization?

    A. anti-IgG and anti-IgM
    B. all of these options
    C. anti-IgG and anti-C3d
    D. anti-IgG and anti-C3a
    C. anti-IgG and anti-C3d
    (this multiple choice question has been scrambled)
  19. Which of the following distinguishes A1 from A2 blood groups?

    A. An A2 person may form anti-A1; an A1 person will not form anti-A1
    B. A2 antigen will not react with anti-A from a nonimmunized donor; A1 will react with any anti-A
    C. A2 antigen will not react with anti-A, A1 will react strongly (4+)
    D. An A1 person may form anti-A2, an A2 person will not form anti-A1
    A. An A2 person may form anti-A1; an A1 person will not form anti-A1
    (this multiple choice question has been scrambled)
  20. A patient's serum is incompatible with O cells. The patient RBCs give a negative reaction to anti-H lectin. What is the most likely cause of these results?

    A. The patient may be a Bombay
    B. The patient may be a subgroup of A
    C. The patient may have developed alloantibodies
    D. The patient may have an immunodeficiency
    A. The patient may be a Bombay
    (this multiple choice question has been scrambled)
  21. What antibodies are formed by a Bombay individual?

    A. anti-A,B
    B. anti-H
    C. anti-A, B, and H
    D. anti-A and anti-B
    C. anti-A, B, and H
    (this multiple choice question has been scrambled)
  22. Acquired B antigens have been found in:

    A. Bombay individuals
    B. Group A persons
    C. All blood groups
    D. Group O persons
    B. Group A persons
    (this multiple choice question has been scrambled)
  23. Blood is crossmatched on an A positive person with a negative antibody screen. The patient received a transfusion of A positive RBCs 3 years ago. The donors chosen for crossmatch were A positive. The crossmatch was run on the Ortho Provue and yielded 3+ incompatibility. How can these results be explained?

    A. the patient is an A1 with anti-A2
    B. the patient is an A2 with anti-A1
    C. the patient has an antibody to a low-frequency antigen
    D. the patient has an antibody to a high-frequency antigen
    B. the patient is an A2 with anti-A1
    (this multiple choice question has been scrambled)
  24. A patient's red cells forward as group O, serum agglutinates B cells (4+) only. Your next step would be:

    A. incubate washed red cells with anti-A1 and anti-A,B for 30 minutes at room temperature
    B. perform an antibody screen including a room temperature incubation
    C. extend reverse typing for 15 minutes
    D. Test patient's red cells with Dolichos biflorus
    A. incubate washed red cells with anti-A1 and anti-A,B for 30 minutes at room temperature
    (this multiple choice question has been scrambled)
  25. Which typing results are most likely to occur when a patient has an acquired B antigen?

    A. anti-A 3+, anti-B neg, A1 cells neg, B cells neg
    B. anti-A 4+, anti-B 4+, A1 cells 2+, B cells neg
    C. anti-A 4+, anti-B 3+, A1 cells neg, B cells neg
    D. anti-A 4+, and-B 1+, A1 cells neg, B cells 4+
    D. anti-A 4+, and-B 1+, A1 cells neg, B cells 4+
    (this multiple choice question has been scrambled)
  26. Which blood group has the least amount of H antigen?

    A. A1
    B. A2
    C. B
    D. A1B
    D. A1B
    (this multiple choice question has been scrambled)
  27. What type RBCs can be transfused to an A2 person with anti-A1?

    A. A only
    B. A or O
    C. B
    D. AB
    B. A or O
    (this multiple choice question has been scrambled)
  28. What should be done if all forward and reverse ABO results as well as the autocontrol are positive?

    A. retype the sample using a different lot number of reagent
    B. report the sample as group AB
    C. Wash the cells with warm saline, autoadsorb the serum at 4oC
    D. use polyclonal typing reagents
    C. Wash the cells with warm saline, autoadsorb the serum at 4oC
    (this multiple choice question has been scrambled)
  29. What should be done if all forward and reverse ABO results are negative?

    A. incubate at 22oC or 4oC to enhance weak expression
    B. repeat the test with new reagents
    C. perform additional testing such as typing with anti-A1 lectin and anti-A,B
    D. run an antibody identification panel
    A. incubate at 22oC or 4oC to enhance weak expression
    (this multiple choice question has been scrambled)
  30. N-acetyl-D-galactosamine is the immunodominant carbohydrate that reacts with:

    A. Arachis hypogaea
    B. Salvia sclarea
    C. Dolichos biflorus
    D. Ulex europeaus
    C. Dolichos biflorus
    (this multiple choice question has been scrambled)
  31. A stem cell transplant patient was retyped when she was transferred from another hospital. What is the most likely cause of the following results?

    patient cells:     Anti-A, neg          Anti-B, 4+
    patient serum:  A1 cells, neg        B cells, neg

    A. alloantibodies
    B. immunodeficiency
    C. autoimmune hemolytic anemia
    D. viral infection
    B. immunodeficiency
    (this multiple choice question has been scrambled)
  32. What reaction would be the same for an A1 and an A2 person?

    A. equal reaction with anti-H
    B. positive reaction with anti-A,B
    C. positive reaction with A1 cells
    D. positive reaction with anti-A1 lectin
    B. positive reaction with anti-A,B
    (this multiple choice question has been scrambled)
  33. A female patient at 28 weeks' gestation yields the following results:

    patient cells:                        Anti-A 3+     Anti-B 4+
    patient serum: A1 cells, neg   B cells, 1+    O cells 1+

    a. hypogammaglobulinemia
    b. alloantibody in patient serum
    c. acquired B
    d. weak subgroup
    b. alloantibody in patient serum
  34. Which condition would most likely be responsible for the following typing results?

    patient cells:    Anti-A, neg     Anti-B, neg
    patient serum: A1 cells, neg   B cells, 4+

    A. masking of antigens by the presence of massive amounts of antibody
    B. impossible to determine
    C. immunodeficiency
    D. weak or excessive antigen(s)
    D. weak or excessive antigen(s)
    (this multiple choice question has been scrambled)
  35. Which of the following results is most likely discrepant?

    Anti-A, neg                    Anti-B, 4+
    A1 cells, neg                  B cells, neg

    A. no problem with this typing
    B. positive reaction with anti-B
    C. negative B cells
    D. negative A1 cells
    D. negative A1 cells
    (this multiple choice question has been scrambled)
  36. A 61-year-old male with a history of multiple myeloma had a stem cell transport 3 years ago. The donor was O positive and the recipient was B positive. He is admitted to a community hospital for fatigue and nausea. Typing results reveal the following:

    anti-A = 0
    anti-B = 0
    anti-A,B = 0
    anti-D = 4+
    A1 cells = 4+
    B cells = 0

    How would you report this type?

    A. A positive
    B. O positive
    C. B positive
    D. Undetermined
    D. Undetermined
    (this multiple choice question has been scrambled)

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