Amyloid precursor protein (APP)
Presenilin 1, presenilin 2 (early onset)
E4 allele of apolipoprotein E
- Genetic or acquired defects in APP processing result in accumulation of amyloid
- containing A4Beta.
- ? Amyloid is a primary or secondary event.
- Amyloid plaques and cerebral amyloid angiopathy.
Neurofibrillary tangles- Paired helical filaments with hyperphosphorylated tau in neurons.