A Pharm - Diuretics

Home > Preview

The flashcards below were created by user bgroll on FreezingBlue Flashcards.


  1. What is the mechanism of action of Thiazides?
    Where is the site of action?
    Thiazides are ___ _______.
    • inhibit Na and Cl reabsorbtion
    • ascending loop of henle
    • K wasting
  2. Name 4 thiazides:
    • Chlorothiazide
    • hydrochlorothiazide
    • benzthiazide
    • cyclothiazide
  3. Clinical uses of Thiazides:
    • essential HTN
    • Edema
    • Diabetes insipidus
    • hypercalcemia
  4. What are the short and long term affects of Thiazides?
    • short term:  decrease extracellular volume and CO
    • long term:  peripheral vasodilation.
  5. What is the major side effect of Thiazides?
    • HypoK HypoCl metabolic acidosis
    • dysrhthmias
    • HYPERURICEMIA (gout aggravation)
    • renal and hepatic failure?
  6. Name two LOOP Diuretics:
    • Ethacrynic Acid
    • Furosemide
  7. Loop diuretics _______ ___ reabsorption in the medullary portion of ascending ____ __ _____.
    • inhibit ion
    • loop of henle
  8. Loop diuretics are NOT USED to treat _________ ___.
    Essential HTN
  9. What are 3 clinical uses for Loop diuretics?
    • Edema mobilization
    • ICP tx (but mannitol preferred)
    • Diff dx of oliguria
  10. What are side fx of LOOP Diuretics?
    • fluid/ ion imbalance
    • hypokalemia
    • increase digitalis tox
    • potentiate NMB's
    • Hyperuricemia
    • Aminoglycoside tox (by inc plasma conc)
    • sulfonamide allergy (sulfur in molecule!)
  11. Pt's with a sulfonamide allergy may be allergic to what diuretic?
    Loop
  12. Name 2 Osmotic Diuretics:
    • Mannitol
    • Urea
  13. Osmotic Diuretics are freely filterable at the __________, undergo _______ reabsorption, ______ __________, and are pharmacology _____.
    • glomerulus
    • limited
    • resist metabolism
    • inert
  14. What is the mechanism of action of Osmotic Diuretics?
    • increases osmolarity of renal tubular fluid, prevents reabsoption of water.
    • increase plasma osmolarity
  15. Name clinical uses for Osmotic Diuretics include prophylaxis against _____ _______, diff dx of ________, tx of increased ___, and reduction of _____________ pressure.
    • renal failure
    • oliguria
    • ICP
    • intraocular
  16. Two K+ sparing diuretics include, T__________, and A________.
    • Triamterene
    • Amiloride
  17. What area of the kidneys do K+ sparing diuretics affect? Why are the used? What is a side effect?
    • convoluted tubules
    • used with other diuretics or in place of a diuretic if low K+ is a concern
    • HYPERKALEMIA
  18. What are the side effects of Osmotic Diuretics?
    • Pulmonary Edema
    • Hypovolemia
    • Electrolyte imbalance
    • plasma hyperosmolarity
  19. Name one Aldosterone Antagonist:  What is a clinical use?
    • Spirinolactone
    • tx of ascites
  20. Carbonic anhydrase inhibitors include the drug A____________, which fx the __________ ducts and inhibit ______ reabsoption.  They are used clinically for ___ surgery.
    • Acetazolamide
    • collecting
    • NaHCO3
    • EYE

Card Set Information

Author:
bgroll
ID:
226321
Filename:
A Pharm - Diuretics
Updated:
2013-07-08 17:16:06
Tags:
aa emory
Folders:

Description:
exam 3
Show Answers:

What would you like to do?

Home > Flashcards > Print Preview