Quiz 2 pt 2(ch 34) current topics of cell bio.txt

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rincrocci
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226348
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Quiz 2 pt 2(ch 34) current topics of cell bio.txt
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2013-07-08 17:17:52
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  1. 1800s Microtubules
    • observed as mitotic fibers
    • microtubule spindles separate chromosomes
  2. 1960s Microtubules
    observed in Electron Micrographs via immunostaining
  3. Spindle apparatus, centrosome & centrioles discovered
    • Interphase MT array
    • cilia & flagella
  4. Microtubules involved in…
    • 1. Cell movement: cilia and flagella
    • 2. InTRAcellular movement
    • 3. Maintaining cell structure
    • 4. Cell SIGNALING
  5. Tubulin binding drugs
    • Colchicine and Nocodazole: binds tubilin dimers to inhibit polymerization
    • Taxol: Binds Microtubules (used for cancer chemo)
  6. Tubulin discovery
    1960's purified from cilia and brain
  7. Microtubule binding proteins and polymerization properties discovery
    • MBP in 1970's
    • pol prop in 1980's

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