A pharm- antihypertensives- VASODILATORS

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Anonymous
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226350
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A pharm- antihypertensives- VASODILATORS
Updated:
2013-07-08 17:45:13
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aa emory
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vasodilators
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  1. methemoglobinemia and cyanide poisoning are caused by what vasodilating drug?
    SNP
  2. name 6 peripheral vasodilators:
    Sat night high (@ the) PTA
    • SNP
    • NTG
    • Hydralazine
    • Papavarine
    • Trimethaphan
    • Adenosine
  3. When should vasodilators be used and why?
    • HTN crisis tx, controlled HTN, improve LV SV for CHF or regurge.
    • can be "finely controlled"
  4. what is mechanism of vasodilators and what does it do?
    NO, decreases SVR and RA filling
  5. NO production is related to what second messenger?
    cGmp
  6. NO is a chemical messenger that helps maintain __ tone, plt __________ and ___ ____________.  Also aids in __ relaxation and immune function.
    • CV
    • aggregation
    • CNS signaling
    • GI
  7. NO duration and inactivation:
    • 5 seconds
    • hemoglobin
  8. What are phys fx of NO?
    arteries dilate more than veins, basal PVr/SVR, cardiac output distribution management.  (naturally)
  9. name "other" FX of NO: PPNI
    • pulmonary bronchodilation
    • plt aggregation
    • NT
    • Immune fx
  10. Essential HTN is thought to be cuase by a decrease in __ production.
    NO
  11. clinical uses of NO
    • inhaled=
    • pulmonary HTN (common with lung transplants),
    • ARDS
  12. when using what drug, increase FGF to greater than ______ ___________
    • NO
    • minute ventilation
  13. SNP is not what?
    selective. dilates veins as much as arteries. causes decrease in preload and afterload
  14. what is the dose, onset and duration of SNP?
    • 0.3-20mcg/kg/min
    • 30 sec
    • 1 min
  15. Cyanide tox can be seen at what dose of SNP?
    >2mcg/kg/min
  16. at low doses, SNP will cause a greater ________ than ________
    • afterload
    • preload (think alphabetical order)
  17. What a few bad things about SNP?
    • light sensitive
    • reflex tachy
    • vascular steal
    •  ischemia
    • rebound HTN
    • increased ICP risk
    • inhibit plt fxn
    • Thiocyanate, cyanide, mgbh
    • N/V from drop in BP
  18. what happens with cyanide tox?
    how should is be treated?
    • tissue anoxia, anaerobic metabolism, lactic acidosis
    • stop SNP, hyperventilate, give bicarb, Na thiosulfate
  19. what is the tx of thiocyanate tox?  why does it occur and what are symptoms?
    • dialysis
    • impaired renal clearance
    • fatigue, tinnitus, N/V
  20. Tx for MHGBemia. Pulse ox reading?
    • methylene blue
    • 85%
  21. Why is SNP used?
    • controlled hypotension
    • HTN emergencies
    • cardiac dz
    • aortic surgery
  22. NTG mostly dilates ______.  Decreases ________ ____ tension.
    • Venous
    • Ventricular wall
  23. Why is NTG taken sublingual?
    bypass 1st pass metabolism
  24. What is the Mechanism of NTG?
    pharmicokinetics?
    organ fx?
    • cGMP
    • short 1/2 life
    • uterine relaxation
  25. Uses of NTG:
    • angina pectoris
    • cardiac failure
    • acute HTN
    • controlled hypotension
  26. Hydralazine is mainly a ________ dilator.  Onset?
    Side fx?
    Use?
    • ARTERIAL
    • 15-20 min
    • reflex tachy, rash, headache, flushing, angina
    • HTN
  27. Hyrdalazine maintains blood flow to ______.  what are 2 bad side fx?
    • Uterus
    • coronary steal, lupus like syndrome
  28. Adenosine has a half life of ___ to ____ sec and is used to treat ____.  it is an _________ nucleotide and potent _______ ___________.
    • 0.6 to 1.5
    • PSVT
    • endogenous
    • coronary vasodilator
  29. What are side fx of trimethaphan?
    midriasis, stomach cramping

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