Pharmacology Abbreviated

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Author:
certainlygirl
ID:
226427
Filename:
Pharmacology Abbreviated
Updated:
2013-07-09 02:48:13
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USMLE pharm Step1
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The absolute bare minimum
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  1. Cyclosporine
    • blocks calcinurin --> blocks IL-2
    • #1 for organ transplant
    • causes gingival hyperplasia
  2. Tacrolimus
    • like cyclosporin, 'cept FK-binding to block calcineurin --> block IL-2
    • organ transplant
  3. Sirolumus
    • block mTor --> block IL-2
    • kidney transplant
    • leukopenia
  4. Azathioprine
    • precursor of 6-MP
    • kidney transplant
    • bone marrow suppression (taken w/ allopurinol makes this worse)
  5. Muromonab (OKT3)
    • blocks CD3 T cell signaling
    • kidney transplantcy
    • cytokine release syndrome
  6. Infliximab
    • blocks TNF-α
    • C.R.A.P.: Crohn's, RA, psoriatic arthritis, ankylosing spondylitis
  7. Adalimumab
    • blocks TNF-α
    • Crohn's, RA, psoriatic arthritis
  8. Rituximab
    • blocks CD20
    • B-cell non-Hodgkin's lymphona
  9. Omalizumab
    • blocks IgE
    • severe asthma
  10. α-interferon
    Hep B & C, Kaposi, leukemia, melanoma
  11. Aldesleukin (IL-2)
    Renal cell carcinoma, melanoma
  12. Filgrastim
    Bone marrow recovery
  13. β-interferon
    Multiple sclerosis (MS)
  14. Bethanecol
    • ACh-like
    • activates bladder smooth muscle to help you pee when you can't
    • (also bowel)
  15. Carbachol
    • ACh-like
    • Closed-angle glaucoma (causes miosis, relieves symptoms by reducing angle)
  16. Pilocarpine
    • ACh-like
    • Open-angle glaucoma (causes miosis, relieves symptoms by reducing angle)
    • induce sweat, tears, saliva (tx dry mouth)
  17. Methacholine
    • ACh-like
    • closes airways (challenge test for asthma)
  18. Neostigmine
    • AChE inhibitor
    • ↑ Ach
    • reverse neuromuscular jnc blockade (postoperative)
    • myasthenia gravis
  19. Edrophonium
    • AChE inhibitor
    • ↑ ACh
    • myasthenia gravis
  20. Physostigmine
    • AChE inhibitor
    • ↑ ACh
    • Open-angle glaucoma (PHYS for the EYES)
  21. Echothiophate
    • AChE inhibitor
    • Open-angle glaucoma
  22. AChE irreversible inhibitors (poisoning, due to organophosphates (insecticides, like parathion))
    Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating, and Salivation

    Antidote: atropine & pralidoxime (regenerates active AChE)
  23. Atropine
    • Muscarinic antagonist (i.e. anticholinergic)
    • Product mydriasis for eye surgery
    • Reverse bradycardia
  24. Homatropine, tropicamide
    • Muscarinic antagonist (i.e. anticholingergic)
    • eye drops - causes mydriasis
  25. Benztropine
    • Muscarinic antagonist (i.e. anticholinergic)
    • inhibits dopamine storage and reuptake (Parkinson's disease)

    PARK my BENZ
  26. Scopolamine
    • Muscarinic antagonist (i.e. anticholinergic)
    • motion sickness on cruise
  27. Oxybutynin
    • M3 Muscarinic antagonist (i.e. anticholinergic)
    • Tx URGE incontinence (leakage) - blocks bladder
  28. Glycopyrrolate
    • Anticholinergic
    • known as: Reduction of secretion
    • drooling people in ICU
    • COPD
  29. Propantheline
    • Anticholinergic
    • used when GI is overacting - slows down GI movement

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