-
Cyclosporine
- blocks calcinurin --> blocks IL-2
- #1 for organ transplant
- causes gingival hyperplasia
-
Tacrolimus
- like cyclosporin, 'cept FK-binding to block calcineurin --> block IL-2
- organ transplant
-
Sirolumus
- block mTor --> block IL-2
- kidney transplant
- leukopenia
-
Azathioprine
- precursor of 6-MP
- kidney transplant
- bone marrow suppression (taken w/ allopurinol makes this worse)
-
Muromonab (OKT3)
- blocks CD3 T cell signaling
- kidney transplantcy
- cytokine release syndrome
-
Infliximab
- blocks TNF-α
- C.R.A.P.: Crohn's, RA, psoriatic arthritis, ankylosing spondylitis
-
Adalimumab
- blocks TNF-α
- Crohn's, RA, psoriatic arthritis
-
Rituximab
- blocks CD20
- B-cell non-Hodgkin's lymphona
-
-
α-interferon
Hep B & C, Kaposi, leukemia, melanoma
-
Aldesleukin (IL-2)
Renal cell carcinoma, melanoma
-
Filgrastim
Bone marrow recovery
-
β-interferon
Multiple sclerosis (MS)
-
Bethanecol
- ACh-like
- activates bladder smooth muscle to help you pee when you can't
- (also bowel)
-
Carbachol
- ACh-like
- Closed-angle glaucoma (causes miosis, relieves symptoms by reducing angle)
-
Pilocarpine
- ACh-like
- Open-angle glaucoma (causes miosis, relieves symptoms by reducing angle)
- induce sweat, tears, saliva (tx dry mouth)
-
Methacholine
- ACh-like
- closes airways (challenge test for asthma)
-
Neostigmine
- AChE inhibitor
- ↑ Ach
- reverse neuromuscular jnc blockade (postoperative)
- myasthenia gravis
-
Edrophonium
- AChE inhibitor
- ↑ ACh
- myasthenia gravis
-
Physostigmine
- AChE inhibitor
- ↑ ACh
- Open-angle glaucoma (PHYS for the EYES)
-
Echothiophate
- AChE inhibitor
- Open-angle glaucoma
-
AChE irreversible inhibitors (poisoning, due to organophosphates (insecticides, like parathion))
Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating, and Salivation
Antidote: atropine & pralidoxime (regenerates active AChE)
-
Atropine
- Muscarinic antagonist (i.e. anticholinergic)
- Product mydriasis for eye surgery
- Reverse bradycardia
-
Homatropine, tropicamide
- Muscarinic antagonist (i.e. anticholingergic)
- eye drops - causes mydriasis
-
Benztropine
- Muscarinic antagonist (i.e. anticholinergic)
- inhibits dopamine storage and reuptake (Parkinson's disease)
PARK my BENZ
-
Scopolamine
- Muscarinic antagonist (i.e. anticholinergic)
- motion sickness on cruise
-
Oxybutynin
- M3 Muscarinic antagonist (i.e. anticholinergic)
- Tx URGE incontinence (leakage) - blocks bladder
-
Glycopyrrolate
- Anticholinergic
- known as: Reduction of secretion
- drooling people in ICU
- COPD
-
Propantheline
- Anticholinergic
- used when GI is overacting - slows down GI movement
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