Quiz 3 (ch 34 MFs) current topics of cell bio.txt

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rincrocci
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226561
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Quiz 3 (ch 34 MFs) current topics of cell bio.txt
Updated:
2013-07-10 13:50:06
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MTs
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MTs
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  1. Microtubule roles
    • Highly Dymanic assemb/disassemb
    • 1. cell shape
    • 2. cell motility
    • 3. intracellular motility
    • 4. cell signaling
    • 5. org of cytoplasm
    • 6. karyokinesis
  2. IF roles
    cell/tissue structure and integrity, along with nuclear structure & integrity
  3. Tubulin gene families
    • a and b: form heterodimers (one + end..GTP exchanges, other - end, no GTP exchange)
    • gamma tubulin: most imp in centrosome organizing center
  4. protofilaments
    • microtubules composed of 13 protofilaments
    • polar, like actin, and + end assembly, - end is nucleations site
    • in vivo no assembly at - end
  5. a and b tubulin isoforms
    • b1: ubiq, essential
    • b2: male specif, resp for sperm tail
    • b3: developmental related
    • b4: expressed at low levels
  6. microtubule binding proteins
    • Binding & stabilizing: Tau, MAPs (2&4)
    • destabilizing: Op18/stathmin, Katanin (severing), XKCM, MCAK
    • Surfacing MAPS: link membrane to + end (CLIP170)
  7. Centrosome
    • composed of 2 centrioles and PCM(pericentriolar material)
    • PCM composed of y-TuRC
  8. Centrioles and replication
    • They replicate in S phase
    • dAUGHTER cells mature via y-TuRC recruitment

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