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The flashcards below were created by user
rincrocci
on FreezingBlue Flashcards.
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Microtubule roles
- Highly Dymanic assemb/disassemb
- 1. cell shape
- 2. cell motility
- 3. intracellular motility
- 4. cell signaling
- 5. org of cytoplasm
- 6. karyokinesis
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IF roles
cell/tissue structure and integrity, along with nuclear structure & integrity
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Tubulin gene families
- a and b: form heterodimers (one + end..GTP exchanges, other - end, no GTP exchange)
- gamma tubulin: most imp in centrosome organizing center
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protofilaments
- microtubules composed of 13 protofilaments
- polar, like actin, and + end assembly, - end is nucleations site
- in vivo no assembly at - end
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a and b tubulin isoforms
- b1: ubiq, essential
- b2: male specif, resp for sperm tail
- b3: developmental related
- b4: expressed at low levels
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microtubule binding proteins
- Binding & stabilizing: Tau, MAPs (2&4)
- destabilizing: Op18/stathmin, Katanin (severing), XKCM, MCAK
- Surfacing MAPS: link membrane to + end (CLIP170)
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Centrosome
- composed of 2 centrioles and PCM(pericentriolar material)
- PCM composed of y-TuRC
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Centrioles and replication
- They replicate in S phase
- dAUGHTER cells mature via y-TuRC recruitment
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