Dental Pulp Chapter 1

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  1. What signals end of odontogenesis?
  2. What influences enamel biomineralization?
    Stratum Intermedium, it expresses alkaline phosphatase
  3. What signals inner DE to differentiate into ameloblasts?
    predentin matrix deposition by odontoblasts in Late Bell Stage
  4. What are knockout mice?
    mice that have a gene removed from their embryonic stem cells in placed in fertilized egg, they lack the gene throughout their lifespan
  5. What are transgenic mice?
    Mice that have a gene inserted into the fertilized egg and is overexpressed where it is normally, it can be placed ectopically into organs where it is not normally expressed
  6. Where do stem cells on dental pulp reside?
    Perivascular niche
  7. What is predentin rich in?
    Type 1 Collagen
  8. Mutation in what gene is responsible for the defects seen in DI Type 2 and 3?
    DSPP Gene
  9. What gene mutation causes DI Type 1?
    Type 1 Collagen
  10. What category of proteins is responsible in mineralization of dentin?
  11. What are the three steps of ondontoblast differentiation?
    Induction, Competence, and Terminal Differentiation
  12. What is one of the hallmarks of terminal odontoblast differentiation?
    Nuclear repolarization
  13. What is the functional terminology for tooth development?
    Initiation, Morphogenesis, Cytodifferentiation, Matrix Apposition
  14. At what stage is the inductive potential transferred from the DE to the DP?
    Bud stage
  15. Dental papilla is termed ____ ____ at late bell stage.
    dental pulp
  16. What is the stellate recticulum?
    Star shaped cell network that secretes high levels of GAGs which sequester fluid and GFs to expand the size of the enamel organ
  17. What is the Trowell type system?
    Mandibular and maxillary explants as well as molar organs can be cultured in enriched serum on a metal grid
  18. What are bead implantation assays?
    Heparin or agarose beads that are soaked in known concentrations of growth factor placed on separated mesenchyme, after 24 hours changes are observed
  19. What are the two types of stem cells?
    Embryonic and Postnatal
  20. What is biologic redundancy?
    When a gene is deleted in knockout mice the affect is not noticed since other genes within the same family cover for the gene deleted.
  21. BMP 2,4 knockout mice undergo _____ _____ during _____ ______.
    embryonic, lethality AND early, gestation
  22. What happens to mice with absent Tgf-β1 gene?
    Significant destruction of pulp and periradicular tissues as wells the hard tissues of the crown. No other TGF-β family members can substitute for the loss of β1
  23. What characterizes cleidocranial dysplasia?
    Open fontanels, defective clavicles, multiple supernumerary teeth that fail to erupt, tooth matrix defects
  24. What gene mutation is suspected in cleidocranial dysplasia?
    Runx2 a osteoblast transcription factor formerly known as Cbfa1 (core binding factor a1).
  25. What is the morphogenic gradient in a developing tooth?
    Most differentiated cells align at the tooth epithelial-mesenchyme interface and less-differentiated cells toward the core of the papilla
  26. When do primary enamel knots appear?
    Late bud stage
  27. _____ is exclusively expressed in enamel knots
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Dental Pulp Chapter 1
2013-07-14 20:02:45
Dental Pulp Quiz

Bender's Dental Pulp Book
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