Do all motor proteins "walk" in the same direction along cytoskeleton filaments? If no, what is the significance of directionality for the cell? Provide some examples of motors that walk in different directions.
- The structure of these proteins dictate if they will be moving in the forwards or reverse direction.
- Myosin: most walk towards the barbed (positive) end of actin filaments (Myo 6 goes towards neg). Most of these are dimers, but some monomers
- Kinesin: most walk towards the Positive end, except for 14, which is C terminal directed, walking towards the negative end. Most dimerize except for Kinesin 3 (monomer)
- Dyneins: mostly all walk towards negative end of microtubules. All are dimers, or trimers