Cartilage

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Author:
ghrelin23187
ID:
227286
Filename:
Cartilage
Updated:
2013-07-16 13:43:57
Tags:
system
Folders:

Description:
cartilage and bone
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  1. Cartilage consists of
    chondrocytes embedded within an extracellular matrix (ECM).
  2. Cartilage is classified into
    three varieties:

    –Hyaline cartilage

    –Elastic cartilage

    –Fibrocartilage
  3. The specific properties of cartilage is derived from
    the makeup of their matrix
  4. True or false:

    Cartilage has a rich pool of blood vessels, lymphatics and nerves
    false
  5. What is the most common type of cartilage?
    Hyaline cartilage
  6. where is the hyaline cartilage located at?
    at synovial joint surfaces, the nose, larynx, trachea, bronchi, and costal cartilages.
  7. Hyaline cartilage - the chondrocytes resides within...
    the lacunae
  8. Hyaline cartilage - Lacunae are located within
    a basophillic extracellular matrix
  9. hyaline cartilage - isogenous group
    the type of arrangement in cluster of chondrocytes 

    they are formed by one or more divisions of an original progenitor chondrocytes
  10. The ECM of hyaline cartilage includes
    the territorial matrix, immediately adjacent to the lacunae

    the interterritorial matrix- the rest of the ECM not immediately adjacent to lacunae.
  11. Hyaline cartilage matrix - Territorial matrix
    contains a high proportion of proteoglycans and is poor in collagen content; this enrichment of proteoglycans increases the basophilia of the matrix just adjacent to the lacunae.
  12. Hyaline Cartilage Matrix- interterritorial matrix
    higher proportion of Type II collagen and lower amounts of proteoglycan 

    • Proteoglycans are organized as aggrecans-
    • glycosaminoglycan molecules covalently bound to a central protein core.

    • The interterritorial matrix is rich in aggrecan
    • molecules that are then linked non- covalently to hyaluronic acid.

    • The high negative charge of these aggrecan
    • complexes results in a net influx of water (~80% by weight of the cartilage) molecules into the matrix.

    Proteoglycan complexes are interspersed among collagen fibers, which are oriented to best resist stress on the cartilage.
  13. Perichondrium - location
    Adjacent to the chondrocytes and their matrix is a region of dense irregular connective tissue
  14. Perichondrium - resident cells
    fibroblasts and chondroblasts
  15. perichondrium - chondroblast
    elongatedcells located between the chondrocyte layer and the fibroblast layer

    •Chondroblasts are a stem population that will produce chondrocytes during growth and maintenance of the cartilage.
  16. True or false 

    Perichondrium is vascular and innervated
    true
  17. true or false
    perichondium is found at articular surfaces
    false
  18. Growth of the cartilage
    • 2 ways:
    • appositional growth
    • interstitial growth
  19. Growth of cartilage - appositional growth
    • From the incorporation of chondroblasts into
    • the cartilage at the interface with perichondrium
  20. growth of cartilage - interstitial growth
    • From the division of chondrocytes within
    • the cartilage itself- this forms the clustering structure of the isogenous groups
  21. no perichondrium is ever found in
    bone plate or joint capsule end (aka articular surface)
  22. Elastic Cartilage is found in
    pinna of the ear, auditory tube, epiglottis, and cuneiform cartilages of the larynx.
  23. Elastic vs hyaline cartilage
    elastic fibers are present in both the matrix and the outer fibrous layer of the perichondrium.
  24. Elastic cartilage - the matric
    • less abundant, and elastic fiber bundles
    • are larger in the territorial vs interterritorial
    • matrices.
  25. Elastic cartilage contain type ... cartilage
    II
  26. Elastic fibers stain ... in many histological preparations of cartilage.
    black
  27. Fibrocartilage - location
    • the intervertebral discs, pubic symphysis,
    • articular discs, and attached to bones.
  28. True or false
    perichondrium play an important role in growth of fibrocartilage
    false
  29. Fribrocartilage - matrix
    scarce

    contain large bundle of type I collagen course bw parallel rows of chondrocytes

    fibers are acidophillic
  30. How is fibrocartilage's collagen bundle arranged?
    in direction of tensile forces 

    e.g: vertically in the annulus fibrosus of the intervetebral discs
  31. Fibrocartilage vs tendon
    both contain Type I collagen, but the morphology of the chondrocyte cell body is round, not flattened
  32. Role of cartilage - hyaline cartilage
    high water contain resist compression force
  33. Role of cartilage - elastic fiber
    provide flexibility
  34. role of cartilage - fibrocartilage
    resist tensile force due to presence of type II cartilage bundles and less matrix moves fibrocartilage closer to bone in its structure

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