***What human genetic disease is associated with defects in the nuclear lamina and what is thought to be the reason behind the effects of the mutations?
Progeria is main disease associated with defects in the nuclear lamina. This is due to a mutation which results in a protein that is not able to become part of the nuclear lamina. The lack of the nuclear lamina to work affects the structure of the nuclear envelope, giving an abnormal shape. This is harmful with cell division, as the lamina cannot provide support to the chomosome organization during mitosis.